STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
RPS4Y140S ribosomal protein S4, Y isoform 1; Belongs to the eukaryotic ribosomal protein eS4 family. (263 aa)    
Predicted Functional Partners:
KDM5D
Lysine-specific demethylase 5D; Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. May play a role in spermatogenesis. Involved in transcriptional repression of diverse metastasis-associated genes; in this function seems to cooperate with ZMYND8. Suppresses prostate cancer cell invasion. Regulates androgen receptor (AR) transcriptional activity [...]
   
 
 0.999
RPS4Y2
40S ribosomal protein S4, Y isoform 2; Belongs to the eukaryotic ribosomal protein eS4 family.
  
0.989
FAU
40S ribosomal protein S30; Belongs to the eukaryotic ribosomal protein eS30 family.
   
 0.989
LOC468581
ubiquitin-60S ribosomal protein L40-like.
   
 0.989
RPS28
Ribosomal protein S28.
   
 0.981
RPS11
Ribosomal protein S11; Belongs to the universal ribosomal protein uS17 family.
  
 0.977
ENSPTRP00000060647
Small subunit ribosomal protein S11e.
  
 0.977
RPS8
40S ribosomal protein S8; Belongs to the eukaryotic ribosomal protein eS8 family.
   
 0.973
RPS20
Ribosomal protein S20.
   
 0.970
RPS3
RPS3 isoform 13; Belongs to the universal ribosomal protein uS3 family.
  
 0.968
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
Server load: low (40%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.