| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| APP | NAE1 | ENSPTRP00000093932 | ENSPTRP00000091978 | Gamma-secretase C-terminal fragment 50; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] | NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Belongs to the ubiquitin-activating E1 family. ULA1 subfamily. | 0.979 |
| CUL1 | CUL1-2 | ENSPTRP00000033967 | ENSPTRP00000086353 | CUL1 isoform 1; Belongs to the cullin family. | Cullin 1. | 0.801 |
| CUL1 | CUL3 | ENSPTRP00000033967 | ENSPTRP00000022190 | CUL1 isoform 1; Belongs to the cullin family. | CUL3 isoform 2; Belongs to the cullin family. | 0.795 |
| CUL1 | ENSPTRP00000084393 | ENSPTRP00000033967 | ENSPTRP00000084393 | CUL1 isoform 1; Belongs to the cullin family. | annotation not available | 0.844 |
| CUL1 | ENSPTRP00000084627 | ENSPTRP00000033967 | ENSPTRP00000084627 | CUL1 isoform 1; Belongs to the cullin family. | annotation not available | 0.713 |
| CUL1 | NAE1 | ENSPTRP00000033967 | ENSPTRP00000091978 | CUL1 isoform 1; Belongs to the cullin family. | NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Belongs to the ubiquitin-activating E1 family. ULA1 subfamily. | 0.761 |
| CUL1 | NEDD8 | ENSPTRP00000033967 | ENSPTRP00000090523 | CUL1 isoform 1; Belongs to the cullin family. | Ubiquitin-like protein Nedd8. | 0.886 |
| CUL1 | UBA3 | ENSPTRP00000033967 | ENSPTRP00000043591 | CUL1 isoform 1; Belongs to the cullin family. | Ubiquitin-like modifier-activating enzyme 3. | 0.813 |
| CUL1 | UBE2F | ENSPTRP00000033967 | ENSPTRP00000087042 | CUL1 isoform 1; Belongs to the cullin family. | Ubiquitin conjugating enzyme E2 F (putative); Belongs to the ubiquitin-conjugating enzyme family. | 0.775 |
| CUL1 | UBE2M | ENSPTRP00000033967 | ENSPTRP00000048453 | CUL1 isoform 1; Belongs to the cullin family. | Ubiquitin conjugating enzyme E2 M; Belongs to the ubiquitin-conjugating enzyme family. | 0.884 |
| CUL1-2 | CUL1 | ENSPTRP00000086353 | ENSPTRP00000033967 | Cullin 1. | CUL1 isoform 1; Belongs to the cullin family. | 0.801 |
| CUL1-2 | CUL3 | ENSPTRP00000086353 | ENSPTRP00000022190 | Cullin 1. | CUL3 isoform 2; Belongs to the cullin family. | 0.795 |
| CUL1-2 | ENSPTRP00000084393 | ENSPTRP00000086353 | ENSPTRP00000084393 | Cullin 1. | annotation not available | 0.844 |
| CUL1-2 | ENSPTRP00000084627 | ENSPTRP00000086353 | ENSPTRP00000084627 | Cullin 1. | annotation not available | 0.713 |
| CUL1-2 | NAE1 | ENSPTRP00000086353 | ENSPTRP00000091978 | Cullin 1. | NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Belongs to the ubiquitin-activating E1 family. ULA1 subfamily. | 0.761 |
| CUL1-2 | NEDD8 | ENSPTRP00000086353 | ENSPTRP00000090523 | Cullin 1. | Ubiquitin-like protein Nedd8. | 0.886 |
| CUL1-2 | UBA3 | ENSPTRP00000086353 | ENSPTRP00000043591 | Cullin 1. | Ubiquitin-like modifier-activating enzyme 3. | 0.813 |
| CUL1-2 | UBE2F | ENSPTRP00000086353 | ENSPTRP00000087042 | Cullin 1. | Ubiquitin conjugating enzyme E2 F (putative); Belongs to the ubiquitin-conjugating enzyme family. | 0.775 |
| CUL1-2 | UBE2M | ENSPTRP00000086353 | ENSPTRP00000048453 | Cullin 1. | Ubiquitin conjugating enzyme E2 M; Belongs to the ubiquitin-conjugating enzyme family. | 0.884 |
| CUL3 | CUL1 | ENSPTRP00000022190 | ENSPTRP00000033967 | CUL3 isoform 2; Belongs to the cullin family. | CUL1 isoform 1; Belongs to the cullin family. | 0.795 |
