MADD protein (Pan troglodytes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

Export your current network:

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file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

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same PNG format, but at higher resolution

... as a vector graphic:

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SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc.

... as short tabular text output:

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TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

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TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

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structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

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node degree of proteins in your network (given the current score cut-off)

... network coordinates:

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a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DENND1A	DENND5A	ENSPTRP00000056001	ENSPTRP00000005844	DENN/MADD domain containing 1A.	DENN/MADD domain containing 5A.	0.479
DENND1A	DENND5B	ENSPTRP00000056001	ENSPTRP00000005843	DENN/MADD domain containing 1A.	DENN domain containing 5B.	0.477
DENND1A	MADD	ENSPTRP00000056001	ENSPTRP00000039153	DENN/MADD domain containing 1A.	MAP kinase activating death domain.	0.734
DENND1A	RAB35	ENSPTRP00000056001	ENSPTRP00000009375	DENN/MADD domain containing 1A.	RAB35, member RAS oncogene family.	0.928
DENND5A	DENND1A	ENSPTRP00000005844	ENSPTRP00000056001	DENN/MADD domain containing 5A.	DENN/MADD domain containing 1A.	0.479
DENND5A	DENND5B	ENSPTRP00000005844	ENSPTRP00000005843	DENN/MADD domain containing 5A.	DENN domain containing 5B.	0.939
DENND5A	MADD	ENSPTRP00000005844	ENSPTRP00000039153	DENN/MADD domain containing 5A.	MAP kinase activating death domain.	0.661
DENND5B	DENND1A	ENSPTRP00000005843	ENSPTRP00000056001	DENN domain containing 5B.	DENN/MADD domain containing 1A.	0.477
DENND5B	DENND5A	ENSPTRP00000005843	ENSPTRP00000005844	DENN domain containing 5B.	DENN/MADD domain containing 5A.	0.939
DENND5B	MADD	ENSPTRP00000005843	ENSPTRP00000039153	DENN domain containing 5B.	MAP kinase activating death domain.	0.649
DMXL2	MADD	ENSPTRP00000086958	ENSPTRP00000039153	DMXL2 isoform 3.	MAP kinase activating death domain.	0.677
MADD	DENND1A	ENSPTRP00000039153	ENSPTRP00000056001	MAP kinase activating death domain.	DENN/MADD domain containing 1A.	0.734
MADD	DENND5A	ENSPTRP00000039153	ENSPTRP00000005844	MAP kinase activating death domain.	DENN/MADD domain containing 5A.	0.661
MADD	DENND5B	ENSPTRP00000039153	ENSPTRP00000005843	MAP kinase activating death domain.	DENN domain containing 5B.	0.649
MADD	DMXL2	ENSPTRP00000039153	ENSPTRP00000086958	MAP kinase activating death domain.	DMXL2 isoform 3.	0.677
MADD	RAB27A	ENSPTRP00000039153	ENSPTRP00000012125	MAP kinase activating death domain.	RAB27A, member RAS oncogene family.	0.708
MADD	RAB27B	ENSPTRP00000039153	ENSPTRP00000017060	MAP kinase activating death domain.	RAB27B, member RAS oncogene family.	0.708
MADD	RAB35	ENSPTRP00000039153	ENSPTRP00000009375	MAP kinase activating death domain.	RAB35, member RAS oncogene family.	0.633
MADD	SYT6	ENSPTRP00000039153	ENSPTRP00000087479	MAP kinase activating death domain.	Synaptotagmin 6.	0.788
MADD	TNF	ENSPTRP00000039153	ENSPTRP00000069905	MAP kinase activating death domain.	Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...]	0.803