MAP2K6 protein (Pan troglodytes) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

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co-expression

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gene neighborhood

gene co-occurrence

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Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPTRP00000061486	MAP2K6	ENSPTRP00000061486	ENSPTRP00000061848	Dual specificity mitogen-activated protein kinase kinase 3 isoform X1.	Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily.	0.989
ENSPTRP00000061486	MAP3K4	ENSPTRP00000061486	ENSPTRP00000073291	Dual specificity mitogen-activated protein kinase kinase 3 isoform X1.	MAP3K4 isoform 5.	0.974
ENSPTRP00000061486	MAP3K5	ENSPTRP00000061486	ENSPTRP00000043317	Dual specificity mitogen-activated protein kinase kinase 3 isoform X1.	Mitogen-activated protein kinase kinase kinase 5.	0.988
ENSPTRP00000061486	MAP3K6	ENSPTRP00000061486	ENSPTRP00000000706	Dual specificity mitogen-activated protein kinase kinase 3 isoform X1.	Mitogen-activated protein kinase kinase kinase 6.	0.972
ENSPTRP00000061486	MAP3K7	ENSPTRP00000061486	ENSPTRP00000057993	Dual specificity mitogen-activated protein kinase kinase 3 isoform X1.	Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.	0.978
ENSPTRP00000061486	MAPK11	ENSPTRP00000061486	ENSPTRP00000074484	Dual specificity mitogen-activated protein kinase kinase 3 isoform X1.	Mitogen-activated protein kinase.	0.978
ENSPTRP00000061486	MAPK12	ENSPTRP00000061486	ENSPTRP00000055595	Dual specificity mitogen-activated protein kinase kinase 3 isoform X1.	Mitogen-activated protein kinase.	0.969
ENSPTRP00000061486	MAPK13	ENSPTRP00000061486	ENSPTRP00000082859	Dual specificity mitogen-activated protein kinase kinase 3 isoform X1.	Mitogen-activated protein kinase 13; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK13 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors such as ELK1 and ATF2. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. MAPK13 is one of the less studie [...]	0.970
ENSPTRP00000061486	MAPK14	ENSPTRP00000061486	ENSPTRP00000030915	Dual specificity mitogen-activated protein kinase kinase 3 isoform X1.	Mitogen-activated protein kinase 14; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK14 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases which are a [...]	0.992
ENSPTRP00000061486	TAOK2	ENSPTRP00000061486	ENSPTRP00000067745	Dual specificity mitogen-activated protein kinase kinase 3 isoform X1.	TAOK2 isoform 1.	0.972
MAP2K6	ENSPTRP00000061486	ENSPTRP00000061848	ENSPTRP00000061486	Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily.	Dual specificity mitogen-activated protein kinase kinase 3 isoform X1.	0.989
MAP2K6	MAP3K4	ENSPTRP00000061848	ENSPTRP00000073291	Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily.	MAP3K4 isoform 5.	0.991
MAP2K6	MAP3K5	ENSPTRP00000061848	ENSPTRP00000043317	Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily.	Mitogen-activated protein kinase kinase kinase 5.	0.996
MAP2K6	MAP3K6	ENSPTRP00000061848	ENSPTRP00000000706	Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily.	Mitogen-activated protein kinase kinase kinase 6.	0.972
MAP2K6	MAP3K7	ENSPTRP00000061848	ENSPTRP00000057993	Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily.	Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.	0.994
MAP2K6	MAPK11	ENSPTRP00000061848	ENSPTRP00000074484	Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily.	Mitogen-activated protein kinase.	0.983
MAP2K6	MAPK12	ENSPTRP00000061848	ENSPTRP00000055595	Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily.	Mitogen-activated protein kinase.	0.979
MAP2K6	MAPK13	ENSPTRP00000061848	ENSPTRP00000082859	Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily.	Mitogen-activated protein kinase 13; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK13 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors such as ELK1 and ATF2. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. MAPK13 is one of the less studie [...]	0.979
MAP2K6	MAPK14	ENSPTRP00000061848	ENSPTRP00000030915	Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily.	Mitogen-activated protein kinase 14; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK14 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases which are a [...]	0.997
MAP2K6	TAOK2	ENSPTRP00000061848	ENSPTRP00000067745	Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily.	TAOK2 isoform 1.	0.980