CSF3 protein (Pan troglodytes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

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node degree of proteins in your network (given the current score cut-off)

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a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADRM1	CSF3	ENSPTRP00000023587	ENSPTRP00000040014	Adhesion regulating molecule 1.	Colony stimulating factor 3 (Granulocyte).	0.946
ADRM1	PSMC4	ENSPTRP00000023587	ENSPTRP00000087250	Adhesion regulating molecule 1.	Proteasome (Prosome, macropain) 26S subunit, ATPase, 4; Belongs to the AAA ATPase family.	0.996
ADRM1	PSMC5	ENSPTRP00000023587	ENSPTRP00000056226	Adhesion regulating molecule 1.	Proteasome (Prosome, macropain) 26S subunit, ATPase, 5; Belongs to the AAA ATPase family.	0.996
ADRM1	PSMD11	ENSPTRP00000023587	ENSPTRP00000015341	Adhesion regulating molecule 1.	Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 11.	0.999
ADRM1	PSMD13	ENSPTRP00000023587	ENSPTRP00000071738	Adhesion regulating molecule 1.	Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 13.	0.992
ADRM1	PSMD6	ENSPTRP00000023587	ENSPTRP00000026037	Adhesion regulating molecule 1.	Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 6.	0.995
CSF3	ADRM1	ENSPTRP00000040014	ENSPTRP00000023587	Colony stimulating factor 3 (Granulocyte).	Adhesion regulating molecule 1.	0.946
CSF3	CSF3R	ENSPTRP00000040014	ENSPTRP00000000960	Colony stimulating factor 3 (Granulocyte).	CSF3R isoform 3.	0.998
CSF3	EPO	ENSPTRP00000040014	ENSPTRP00000033390	Colony stimulating factor 3 (Granulocyte).	Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family.	0.956
CSF3	LEP	ENSPTRP00000040014	ENSPTRP00000072740	Colony stimulating factor 3 (Granulocyte).	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...]	0.930
CSF3	PSMC4	ENSPTRP00000040014	ENSPTRP00000087250	Colony stimulating factor 3 (Granulocyte).	Proteasome (Prosome, macropain) 26S subunit, ATPase, 4; Belongs to the AAA ATPase family.	0.964
CSF3	PSMC5	ENSPTRP00000040014	ENSPTRP00000056226	Colony stimulating factor 3 (Granulocyte).	Proteasome (Prosome, macropain) 26S subunit, ATPase, 5; Belongs to the AAA ATPase family.	0.957
CSF3	PSMD11	ENSPTRP00000040014	ENSPTRP00000015341	Colony stimulating factor 3 (Granulocyte).	Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 11.	0.957
CSF3	PSMD13	ENSPTRP00000040014	ENSPTRP00000071738	Colony stimulating factor 3 (Granulocyte).	Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 13.	0.963
CSF3	PSMD6	ENSPTRP00000040014	ENSPTRP00000026037	Colony stimulating factor 3 (Granulocyte).	Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 6.	0.969
CSF3	THPO	ENSPTRP00000040014	ENSPTRP00000062661	Colony stimulating factor 3 (Granulocyte).	THPO isoform 1.	0.965
CSF3R	CSF3	ENSPTRP00000000960	ENSPTRP00000040014	CSF3R isoform 3.	Colony stimulating factor 3 (Granulocyte).	0.998
CSF3R	EPO	ENSPTRP00000000960	ENSPTRP00000033390	CSF3R isoform 3.	Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family.	0.677
CSF3R	LEP	ENSPTRP00000000960	ENSPTRP00000072740	CSF3R isoform 3.	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...]	0.656
CSF3R	THPO	ENSPTRP00000000960	ENSPTRP00000062661	CSF3R isoform 3.	THPO isoform 1.	0.710