BTLA protein (Pan troglodytes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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structured XML interaction data, according to the 'PSI-MI' data standard

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node degree of proteins in your network (given the current score cut-off)

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a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BCL6	BTLA	ENSPTRP00000068244	ENSPTRP00000040260	BCL6 transcription repressor.	B and T lymphocyte associated.	0.714
BCL6	CD4	ENSPTRP00000068244	ENSPTRP00000054833	BCL6 transcription repressor.	T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...]	0.843
BCL6	CTLA4	ENSPTRP00000068244	ENSPTRP00000080210	BCL6 transcription repressor.	Cytotoxic T-lymphocyte associated protein 4.	0.658
BCL6	CXCR5	ENSPTRP00000068244	ENSPTRP00000073048	BCL6 transcription repressor.	C-X-C motif chemokine receptor 5; Belongs to the G-protein coupled receptor 1 family.	0.835
BTLA	BCL6	ENSPTRP00000040260	ENSPTRP00000068244	B and T lymphocyte associated.	BCL6 transcription repressor.	0.714
BTLA	CD160	ENSPTRP00000040260	ENSPTRP00000081465	B and T lymphocyte associated.	CD160 isoform 5.	0.806
BTLA	CD4	ENSPTRP00000040260	ENSPTRP00000054833	B and T lymphocyte associated.	T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...]	0.813
BTLA	CTLA4	ENSPTRP00000040260	ENSPTRP00000080210	B and T lymphocyte associated.	Cytotoxic T-lymphocyte associated protein 4.	0.751
BTLA	CXCR5	ENSPTRP00000040260	ENSPTRP00000073048	B and T lymphocyte associated.	C-X-C motif chemokine receptor 5; Belongs to the G-protein coupled receptor 1 family.	0.750
BTLA	ENSPTRP00000067174	ENSPTRP00000040260	ENSPTRP00000067174	B and T lymphocyte associated.	annotation not available	0.702
BTLA	LAG3	ENSPTRP00000040260	ENSPTRP00000042500	B and T lymphocyte associated.	LAG3 isoform 3.	0.699
BTLA	PTPN11	ENSPTRP00000040260	ENSPTRP00000061336	B and T lymphocyte associated.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.702
BTLA	PTPN11-2	ENSPTRP00000040260	ENSPTRP00000073224	B and T lymphocyte associated.	Protein tyrosine phosphatase non-receptor type 11.	0.702
BTLA	TNFRSF14	ENSPTRP00000040260	ENSPTRP00000000096	B and T lymphocyte associated.	Tumor necrosis factor receptor superfamily, member 14 (Herpesvirus entry mediator).	0.983
CD160	BTLA	ENSPTRP00000081465	ENSPTRP00000040260	CD160 isoform 5.	B and T lymphocyte associated.	0.806
CD160	CD4	ENSPTRP00000081465	ENSPTRP00000054833	CD160 isoform 5.	T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...]	0.799
CD160	CTLA4	ENSPTRP00000081465	ENSPTRP00000080210	CD160 isoform 5.	Cytotoxic T-lymphocyte associated protein 4.	0.704
CD160	LAG3	ENSPTRP00000081465	ENSPTRP00000042500	CD160 isoform 5.	LAG3 isoform 3.	0.761
CD160	TNFRSF14	ENSPTRP00000081465	ENSPTRP00000000096	CD160 isoform 5.	Tumor necrosis factor receptor superfamily, member 14 (Herpesvirus entry mediator).	0.725
CD4	BCL6	ENSPTRP00000054833	ENSPTRP00000068244	T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...]	BCL6 transcription repressor.	0.843