| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| IL15 | IL2 | ENSPTRP00000068237 | ENSPTRP00000028193 | Interleukin; Belongs to the IL-15/IL-21 family. | Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. | 0.989 |
| IL15 | IL21 | ENSPTRP00000068237 | ENSPTRP00000028194 | Interleukin; Belongs to the IL-15/IL-21 family. | Interleukin; Belongs to the IL-15/IL-21 family. | 0.969 |
| IL15 | IL21R | ENSPTRP00000068237 | ENSPTRP00000061704 | Interleukin; Belongs to the IL-15/IL-21 family. | IL21R isoform 1. | 0.826 |
| IL15 | IL2RA | ENSPTRP00000068237 | ENSPTRP00000003829 | Interleukin; Belongs to the IL-15/IL-21 family. | Interleukin-2 receptor subunit alpha; Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells. | 0.877 |
| IL15 | IL2RB | ENSPTRP00000068237 | ENSPTRP00000024676 | Interleukin; Belongs to the IL-15/IL-21 family. | Interleukin-2 receptor subunit beta; Receptor for interleukin-2. This beta subunit is involved in receptor mediated endocytosis and transduces the mitogenic signals of IL2. Probably in association with IL15RA, involved in the stimulation of neutrophil phagocytosis by IL15 (By similarity). | 0.996 |
| IL15 | IL2RG | ENSPTRP00000068237 | ENSPTRP00000047375 | Interleukin; Belongs to the IL-15/IL-21 family. | IL2RG isoform 1. | 0.993 |
| IL15 | IL4 | ENSPTRP00000068237 | ENSPTRP00000029464 | Interleukin; Belongs to the IL-15/IL-21 family. | Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4. | 0.977 |
| IL15 | IL4R | ENSPTRP00000068237 | ENSPTRP00000013524 | Interleukin; Belongs to the IL-15/IL-21 family. | IL4R isoform 2. | 0.723 |
| IL15 | IL7 | ENSPTRP00000068237 | ENSPTRP00000079272 | Interleukin; Belongs to the IL-15/IL-21 family. | Interleukin-7; Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation. Belongs to the IL-7/IL-9 family. | 0.990 |
| IL15 | JAK1 | ENSPTRP00000068237 | ENSPTRP00000001425 | Interleukin; Belongs to the IL-15/IL-21 family. | Tyrosine-protein kinase. | 0.903 |
| IL2 | IL15 | ENSPTRP00000028193 | ENSPTRP00000068237 | Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. | Interleukin; Belongs to the IL-15/IL-21 family. | 0.989 |
| IL2 | IL21 | ENSPTRP00000028193 | ENSPTRP00000028194 | Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. | Interleukin; Belongs to the IL-15/IL-21 family. | 0.973 |
| IL2 | IL21R | ENSPTRP00000028193 | ENSPTRP00000061704 | Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. | IL21R isoform 1. | 0.816 |
| IL2 | IL2RA | ENSPTRP00000028193 | ENSPTRP00000003829 | Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. | Interleukin-2 receptor subunit alpha; Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells. | 0.999 |
| IL2 | IL2RB | ENSPTRP00000028193 | ENSPTRP00000024676 | Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. | Interleukin-2 receptor subunit beta; Receptor for interleukin-2. This beta subunit is involved in receptor mediated endocytosis and transduces the mitogenic signals of IL2. Probably in association with IL15RA, involved in the stimulation of neutrophil phagocytosis by IL15 (By similarity). | 0.998 |
| IL2 | IL2RG | ENSPTRP00000028193 | ENSPTRP00000047375 | Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. | IL2RG isoform 1. | 0.996 |
| IL2 | IL4 | ENSPTRP00000028193 | ENSPTRP00000029464 | Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. | Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4. | 0.991 |
| IL2 | IL4R | ENSPTRP00000028193 | ENSPTRP00000013524 | Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. | IL4R isoform 2. | 0.815 |
| IL2 | IL7 | ENSPTRP00000028193 | ENSPTRP00000079272 | Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. | Interleukin-7; Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation. Belongs to the IL-7/IL-9 family. | 0.987 |
| IL2 | JAK1 | ENSPTRP00000028193 | ENSPTRP00000001425 | Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. | Tyrosine-protein kinase. | 0.993 |
