| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ARSA | GALC | ENSPTRP00000025086 | ENSPTRP00000011226 | Arylsulfatase A. | Galactosylceramidase. | 0.959 |
| ARSA | GLA | ENSPTRP00000025086 | ENSPTRP00000039846 | Arylsulfatase A. | Alpha-galactosidase. | 0.941 |
| ARSA | GLA-2 | ENSPTRP00000025086 | ENSPTRP00000087461 | Arylsulfatase A. | Galactosidase alpha. | 0.441 |
| ARSA | GM2A | ENSPTRP00000025086 | ENSPTRP00000085826 | Arylsulfatase A. | GM2 ganglioside activator. | 0.509 |
| ARSA | PSAP | ENSPTRP00000025086 | ENSPTRP00000064944 | Arylsulfatase A. | Prosaposin; Prosaposin: Behaves as a myelinotrophic and neurotrophic factor, these effects are mediated by its G-protein-coupled receptors, GPR37 and GPR37L1, undergoing ligand-mediated internalization followed by ERK phosphorylation signaling. | 0.868 |
| ARSA | PSAPL1 | ENSPTRP00000025086 | ENSPTRP00000053714 | Arylsulfatase A. | Proactivator polypeptide-like 1; May activate the lysosomal degradation of sphingolipids. | 0.773 |
| GALC | ARSA | ENSPTRP00000011226 | ENSPTRP00000025086 | Galactosylceramidase. | Arylsulfatase A. | 0.959 |
| GALC | GBA | ENSPTRP00000011226 | ENSPTRP00000051730 | Galactosylceramidase. | Lysosomal acid glucosylceramidase; Glucosylceramidase that catalyzes, within the lysosomal compartment, the hydrolysis of glucosylceramide/GlcCer into free ceramide and glucose. Thereby, plays a central role in the degradation of complex lipids and the turnover of cellular membranes. Through the production of ceramides, participates to the PKC-activated salvage pathway of ceramide formation. Also plays a role in cholesterol metabolism. May either catalyze the glucosylation of cholesterol, through a transglucosylation reaction that transfers glucose from glucosylceramide to cholesterol. [...] | 0.951 |
| GALC | GLA | ENSPTRP00000011226 | ENSPTRP00000039846 | Galactosylceramidase. | Alpha-galactosidase. | 0.939 |
| GALC | GLA-2 | ENSPTRP00000011226 | ENSPTRP00000087461 | Galactosylceramidase. | Galactosidase alpha. | 0.424 |
| GALC | PSAP | ENSPTRP00000011226 | ENSPTRP00000064944 | Galactosylceramidase. | Prosaposin; Prosaposin: Behaves as a myelinotrophic and neurotrophic factor, these effects are mediated by its G-protein-coupled receptors, GPR37 and GPR37L1, undergoing ligand-mediated internalization followed by ERK phosphorylation signaling. | 0.850 |
| GALC | PSAPL1 | ENSPTRP00000011226 | ENSPTRP00000053714 | Galactosylceramidase. | Proactivator polypeptide-like 1; May activate the lysosomal degradation of sphingolipids. | 0.772 |
| GBA | GALC | ENSPTRP00000051730 | ENSPTRP00000011226 | Lysosomal acid glucosylceramidase; Glucosylceramidase that catalyzes, within the lysosomal compartment, the hydrolysis of glucosylceramide/GlcCer into free ceramide and glucose. Thereby, plays a central role in the degradation of complex lipids and the turnover of cellular membranes. Through the production of ceramides, participates to the PKC-activated salvage pathway of ceramide formation. Also plays a role in cholesterol metabolism. May either catalyze the glucosylation of cholesterol, through a transglucosylation reaction that transfers glucose from glucosylceramide to cholesterol. [...] | Galactosylceramidase. | 0.951 |
| GBA | PSAP | ENSPTRP00000051730 | ENSPTRP00000064944 | Lysosomal acid glucosylceramidase; Glucosylceramidase that catalyzes, within the lysosomal compartment, the hydrolysis of glucosylceramide/GlcCer into free ceramide and glucose. Thereby, plays a central role in the degradation of complex lipids and the turnover of cellular membranes. Through the production of ceramides, participates to the PKC-activated salvage pathway of ceramide formation. Also plays a role in cholesterol metabolism. May either catalyze the glucosylation of cholesterol, through a transglucosylation reaction that transfers glucose from glucosylceramide to cholesterol. [...] | Prosaposin; Prosaposin: Behaves as a myelinotrophic and neurotrophic factor, these effects are mediated by its G-protein-coupled receptors, GPR37 and GPR37L1, undergoing ligand-mediated internalization followed by ERK phosphorylation signaling. | 0.831 |
| GBA | PSAPL1 | ENSPTRP00000051730 | ENSPTRP00000053714 | Lysosomal acid glucosylceramidase; Glucosylceramidase that catalyzes, within the lysosomal compartment, the hydrolysis of glucosylceramide/GlcCer into free ceramide and glucose. Thereby, plays a central role in the degradation of complex lipids and the turnover of cellular membranes. Through the production of ceramides, participates to the PKC-activated salvage pathway of ceramide formation. Also plays a role in cholesterol metabolism. May either catalyze the glucosylation of cholesterol, through a transglucosylation reaction that transfers glucose from glucosylceramide to cholesterol. [...] | Proactivator polypeptide-like 1; May activate the lysosomal degradation of sphingolipids. | 0.752 |
| GLA | ARSA | ENSPTRP00000039846 | ENSPTRP00000025086 | Alpha-galactosidase. | Arylsulfatase A. | 0.941 |
| GLA | GALC | ENSPTRP00000039846 | ENSPTRP00000011226 | Alpha-galactosidase. | Galactosylceramidase. | 0.939 |
| GLA | PSAP | ENSPTRP00000039846 | ENSPTRP00000064944 | Alpha-galactosidase. | Prosaposin; Prosaposin: Behaves as a myelinotrophic and neurotrophic factor, these effects are mediated by its G-protein-coupled receptors, GPR37 and GPR37L1, undergoing ligand-mediated internalization followed by ERK phosphorylation signaling. | 0.901 |
| GLA | PSAPL1 | ENSPTRP00000039846 | ENSPTRP00000053714 | Alpha-galactosidase. | Proactivator polypeptide-like 1; May activate the lysosomal degradation of sphingolipids. | 0.842 |
| GLA-2 | ARSA | ENSPTRP00000087461 | ENSPTRP00000025086 | Galactosidase alpha. | Arylsulfatase A. | 0.441 |
