PAK3 protein (Pan troglodytes) - STRING interaction network

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PAK3

Serine/threonine-protein kinase PAK 3; Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, or cell cycle regulation. Plays a role in dendrite spine morphogenesis as well as synapse formation and plasticity. Acts as downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates MAPK4 and MAPK6 and activates the downstrea [...] (580 aa)

Predicted Functional Partners:

CDC42

0.997

ARHGEF6

0.995

NCK1

0.970

NCK2

0.968

PAK1

0.949

LIMK2

0.949

LIMK1-2

0.949

GIT2

0.947

MYO6

0.940

GNG12

0.933

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARHGEF6	CDC42	ENSPTRP00000043151	ENSPTRP00000077648	Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6.	Cell division cycle 42 (GTP binding protein, 25kDa).	0.916
ARHGEF6	GIT2	ENSPTRP00000043151	ENSPTRP00000075299	Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6.	G protein-coupled receptor kinase interacting ArfGAP 2.	0.991
ARHGEF6	GNG12	ENSPTRP00000043151	ENSPTRP00000062287	Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.412
ARHGEF6	NCK1	ENSPTRP00000043151	ENSPTRP00000026594	Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6.	Cytoplasmic protein.	0.837
ARHGEF6	NCK2	ENSPTRP00000043151	ENSPTRP00000021097	Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6.	Cytoplasmic protein.	0.713
ARHGEF6	PAK1	ENSPTRP00000043151	ENSPTRP00000007058	Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6.	Non-specific serine/threonine protein kinase.	0.998
ARHGEF6	PAK3	ENSPTRP00000043151	ENSPTRP00000062580	Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6.	Serine/threonine-protein kinase PAK 3; Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, or cell cycle regulation. Plays a role in dendrite spine morphogenesis as well as synapse formation and plasticity. Acts as downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates MAPK4 and MAPK6 and activates the downstrea [...]	0.995
CDC42	ARHGEF6	ENSPTRP00000077648	ENSPTRP00000043151	Cell division cycle 42 (GTP binding protein, 25kDa).	Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6.	0.916
CDC42	GIT2	ENSPTRP00000077648	ENSPTRP00000075299	Cell division cycle 42 (GTP binding protein, 25kDa).	G protein-coupled receptor kinase interacting ArfGAP 2.	0.963
CDC42	LIMK1-2	ENSPTRP00000077648	ENSPTRP00000079435	Cell division cycle 42 (GTP binding protein, 25kDa).	LIM domain kinase 1.	0.663
CDC42	LIMK2	ENSPTRP00000077648	ENSPTRP00000049722	Cell division cycle 42 (GTP binding protein, 25kDa).	LIMK2 isoform 6.	0.570
CDC42	MYO6	ENSPTRP00000077648	ENSPTRP00000071251	Cell division cycle 42 (GTP binding protein, 25kDa).	MYO6 isoform 3; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.410
CDC42	NCK1	ENSPTRP00000077648	ENSPTRP00000026594	Cell division cycle 42 (GTP binding protein, 25kDa).	Cytoplasmic protein.	0.817
CDC42	NCK2	ENSPTRP00000077648	ENSPTRP00000021097	Cell division cycle 42 (GTP binding protein, 25kDa).	Cytoplasmic protein.	0.536
CDC42	PAK1	ENSPTRP00000077648	ENSPTRP00000007058	Cell division cycle 42 (GTP binding protein, 25kDa).	Non-specific serine/threonine protein kinase.	0.999
CDC42	PAK3	ENSPTRP00000077648	ENSPTRP00000062580	Cell division cycle 42 (GTP binding protein, 25kDa).	Serine/threonine-protein kinase PAK 3; Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, or cell cycle regulation. Plays a role in dendrite spine morphogenesis as well as synapse formation and plasticity. Acts as downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates MAPK4 and MAPK6 and activates the downstrea [...]	0.997
GIT2	ARHGEF6	ENSPTRP00000075299	ENSPTRP00000043151	G protein-coupled receptor kinase interacting ArfGAP 2.	Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6.	0.991
GIT2	CDC42	ENSPTRP00000075299	ENSPTRP00000077648	G protein-coupled receptor kinase interacting ArfGAP 2.	Cell division cycle 42 (GTP binding protein, 25kDa).	0.963
GIT2	NCK1	ENSPTRP00000075299	ENSPTRP00000026594	G protein-coupled receptor kinase interacting ArfGAP 2.	Cytoplasmic protein.	0.732
GIT2	NCK2	ENSPTRP00000075299	ENSPTRP00000021097	G protein-coupled receptor kinase interacting ArfGAP 2.	Cytoplasmic protein.	0.592

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