node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DIS3 | SCN8A | ENSPTRP00000053467 | ENSPTRP00000042161 | DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease; Belongs to the RNR ribonuclease family. | Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. | 0.823 |
FGF14 | SCN2A | ENSPTRP00000010216 | ENSPTRP00000074490 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. | 0.691 |
FGF14 | SCN8A | ENSPTRP00000010216 | ENSPTRP00000042161 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. | 0.814 |
KCNQ2 | SCN1B | ENSPTRP00000023658 | ENSPTRP00000089848 | KCNQ2 isoform 7; Belongs to the potassium channel family. | Sodium channel subunit beta-1; Regulatory subunit of multiple voltage-gated sodium channel complexes that play important roles in excitable membranes in brain, heart and skeletal muscle. Enhances the presence of the pore-forming alpha subunit at the cell surface and modulates channel gating characteristics and the rate of channel inactivation. Modulates the activity of a variety of pore-forming alpha subunits, such as SCN1A, SCN2A, SCN3A, SCN4A, SCN5A and SCN10A. | 0.554 |
KCNQ2 | SCN2A | ENSPTRP00000023658 | ENSPTRP00000074490 | KCNQ2 isoform 7; Belongs to the potassium channel family. | Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. | 0.829 |
KCNQ2 | SCN2B | ENSPTRP00000023658 | ENSPTRP00000072074 | KCNQ2 isoform 7; Belongs to the potassium channel family. | Sodium voltage-gated channel beta subunit 2. | 0.512 |
KCNQ2 | SCN8A | ENSPTRP00000023658 | ENSPTRP00000042161 | KCNQ2 isoform 7; Belongs to the potassium channel family. | Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. | 0.832 |
PDLIM3 | SCN8A | ENSPTRP00000028557 | ENSPTRP00000042161 | PDZ and LIM domain 3. | Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. | 0.790 |
SCN1B | KCNQ2 | ENSPTRP00000089848 | ENSPTRP00000023658 | Sodium channel subunit beta-1; Regulatory subunit of multiple voltage-gated sodium channel complexes that play important roles in excitable membranes in brain, heart and skeletal muscle. Enhances the presence of the pore-forming alpha subunit at the cell surface and modulates channel gating characteristics and the rate of channel inactivation. Modulates the activity of a variety of pore-forming alpha subunits, such as SCN1A, SCN2A, SCN3A, SCN4A, SCN5A and SCN10A. | KCNQ2 isoform 7; Belongs to the potassium channel family. | 0.554 |
SCN1B | SCN2A | ENSPTRP00000089848 | ENSPTRP00000074490 | Sodium channel subunit beta-1; Regulatory subunit of multiple voltage-gated sodium channel complexes that play important roles in excitable membranes in brain, heart and skeletal muscle. Enhances the presence of the pore-forming alpha subunit at the cell surface and modulates channel gating characteristics and the rate of channel inactivation. Modulates the activity of a variety of pore-forming alpha subunits, such as SCN1A, SCN2A, SCN3A, SCN4A, SCN5A and SCN10A. | Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. | 0.948 |
SCN1B | SCN2B | ENSPTRP00000089848 | ENSPTRP00000072074 | Sodium channel subunit beta-1; Regulatory subunit of multiple voltage-gated sodium channel complexes that play important roles in excitable membranes in brain, heart and skeletal muscle. Enhances the presence of the pore-forming alpha subunit at the cell surface and modulates channel gating characteristics and the rate of channel inactivation. Modulates the activity of a variety of pore-forming alpha subunits, such as SCN1A, SCN2A, SCN3A, SCN4A, SCN5A and SCN10A. | Sodium voltage-gated channel beta subunit 2. | 0.987 |
SCN1B | SCN3B | ENSPTRP00000089848 | ENSPTRP00000007545 | Sodium channel subunit beta-1; Regulatory subunit of multiple voltage-gated sodium channel complexes that play important roles in excitable membranes in brain, heart and skeletal muscle. Enhances the presence of the pore-forming alpha subunit at the cell surface and modulates channel gating characteristics and the rate of channel inactivation. Modulates the activity of a variety of pore-forming alpha subunits, such as SCN1A, SCN2A, SCN3A, SCN4A, SCN5A and SCN10A. | Sodium voltage-gated channel beta subunit 3. | 0.756 |
SCN1B | SCN4B | ENSPTRP00000089848 | ENSPTRP00000091439 | Sodium channel subunit beta-1; Regulatory subunit of multiple voltage-gated sodium channel complexes that play important roles in excitable membranes in brain, heart and skeletal muscle. Enhances the presence of the pore-forming alpha subunit at the cell surface and modulates channel gating characteristics and the rate of channel inactivation. Modulates the activity of a variety of pore-forming alpha subunits, such as SCN1A, SCN2A, SCN3A, SCN4A, SCN5A and SCN10A. | Sodium voltage-gated channel beta subunit 4. | 0.983 |
SCN1B | SCN8A | ENSPTRP00000089848 | ENSPTRP00000042161 | Sodium channel subunit beta-1; Regulatory subunit of multiple voltage-gated sodium channel complexes that play important roles in excitable membranes in brain, heart and skeletal muscle. Enhances the presence of the pore-forming alpha subunit at the cell surface and modulates channel gating characteristics and the rate of channel inactivation. Modulates the activity of a variety of pore-forming alpha subunits, such as SCN1A, SCN2A, SCN3A, SCN4A, SCN5A and SCN10A. | Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. | 0.930 |
SCN2A | FGF14 | ENSPTRP00000074490 | ENSPTRP00000010216 | Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | 0.691 |
SCN2A | KCNQ2 | ENSPTRP00000074490 | ENSPTRP00000023658 | Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. | KCNQ2 isoform 7; Belongs to the potassium channel family. | 0.829 |
SCN2A | SCN1B | ENSPTRP00000074490 | ENSPTRP00000089848 | Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. | Sodium channel subunit beta-1; Regulatory subunit of multiple voltage-gated sodium channel complexes that play important roles in excitable membranes in brain, heart and skeletal muscle. Enhances the presence of the pore-forming alpha subunit at the cell surface and modulates channel gating characteristics and the rate of channel inactivation. Modulates the activity of a variety of pore-forming alpha subunits, such as SCN1A, SCN2A, SCN3A, SCN4A, SCN5A and SCN10A. | 0.948 |
SCN2A | SCN2B | ENSPTRP00000074490 | ENSPTRP00000072074 | Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. | Sodium voltage-gated channel beta subunit 2. | 0.973 |
SCN2A | SCN3B | ENSPTRP00000074490 | ENSPTRP00000007545 | Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. | Sodium voltage-gated channel beta subunit 3. | 0.889 |
SCN2A | SCN4B | ENSPTRP00000074490 | ENSPTRP00000091439 | Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. | Sodium voltage-gated channel beta subunit 4. | 0.915 |