| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CFLAR | ITCH | ENSPTRP00000078536 | ENSPTRP00000042219 | CASP8 and FADD-like apoptosis regulator; Belongs to the peptidase C14A family. | E3 ubiquitin-protein ligase. | 0.993 |
| DTX1 | ITCH | ENSPTRP00000009298 | ENSPTRP00000042219 | Deltex E3 ubiquitin ligase 1. | E3 ubiquitin-protein ligase. | 0.945 |
| DTX1 | NOTCH1 | ENSPTRP00000009298 | ENSPTRP00000036924 | Deltex E3 ubiquitin ligase 1. | NOTCH1 isoform 1. | 0.978 |
| DTX1 | NOTCH3 | ENSPTRP00000009298 | ENSPTRP00000018116 | Deltex E3 ubiquitin ligase 1. | NOTCH3 isoform 1. | 0.913 |
| ITCH | CFLAR | ENSPTRP00000042219 | ENSPTRP00000078536 | E3 ubiquitin-protein ligase. | CASP8 and FADD-like apoptosis regulator; Belongs to the peptidase C14A family. | 0.993 |
| ITCH | DTX1 | ENSPTRP00000042219 | ENSPTRP00000009298 | E3 ubiquitin-protein ligase. | Deltex E3 ubiquitin ligase 1. | 0.945 |
| ITCH | MAPK10 | ENSPTRP00000042219 | ENSPTRP00000069952 | E3 ubiquitin-protein ligase. | Mitogen-activated protein kinase. | 0.958 |
| ITCH | MAPK8 | ENSPTRP00000042219 | ENSPTRP00000040692 | E3 ubiquitin-protein ligase. | Mitogen-activated protein kinase. | 0.963 |
| ITCH | NOTCH1 | ENSPTRP00000042219 | ENSPTRP00000036924 | E3 ubiquitin-protein ligase. | NOTCH1 isoform 1. | 0.976 |
| ITCH | NOTCH3 | ENSPTRP00000042219 | ENSPTRP00000018116 | E3 ubiquitin-protein ligase. | NOTCH3 isoform 1. | 0.940 |
| ITCH | NUMB | ENSPTRP00000042219 | ENSPTRP00000045621 | E3 ubiquitin-protein ligase. | NUMB endocytic adaptor protein. | 0.965 |
| ITCH | RNF11 | ENSPTRP00000042219 | ENSPTRP00000061045 | E3 ubiquitin-protein ligase. | Ring finger protein 11. | 0.958 |
| ITCH | TP63 | ENSPTRP00000042219 | ENSPTRP00000027067 | E3 ubiquitin-protein ligase. | Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. | 0.965 |
| ITCH | TP73 | ENSPTRP00000042219 | ENSPTRP00000064772 | E3 ubiquitin-protein ligase. | Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. | 0.967 |
| MAPK10 | ITCH | ENSPTRP00000069952 | ENSPTRP00000042219 | Mitogen-activated protein kinase. | E3 ubiquitin-protein ligase. | 0.958 |
| MAPK10 | MAPK8 | ENSPTRP00000069952 | ENSPTRP00000040692 | Mitogen-activated protein kinase. | Mitogen-activated protein kinase. | 0.901 |
| MAPK10 | TP63 | ENSPTRP00000069952 | ENSPTRP00000027067 | Mitogen-activated protein kinase. | Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. | 0.436 |
| MAPK10 | TP73 | ENSPTRP00000069952 | ENSPTRP00000064772 | Mitogen-activated protein kinase. | Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. | 0.436 |
| MAPK8 | ITCH | ENSPTRP00000040692 | ENSPTRP00000042219 | Mitogen-activated protein kinase. | E3 ubiquitin-protein ligase. | 0.963 |
| MAPK8 | MAPK10 | ENSPTRP00000040692 | ENSPTRP00000069952 | Mitogen-activated protein kinase. | Mitogen-activated protein kinase. | 0.901 |
