| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| BRCA2 | DMC1 | ENSPTRP00000009812 | ENSPTRP00000024757 | Breast cancer 2, early onset. | Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily. | 0.951 |
| BRCA2 | ENSPTRP00000070567 | ENSPTRP00000009812 | ENSPTRP00000070567 | Breast cancer 2, early onset. | annotation not available | 0.771 |
| BRCA2 | RAD51 | ENSPTRP00000009812 | ENSPTRP00000068995 | Breast cancer 2, early onset. | DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] | 0.999 |
| BRCA2 | RAD51B | ENSPTRP00000009812 | ENSPTRP00000081962 | Breast cancer 2, early onset. | RAD51B isoform 1. | 0.927 |
| BRCA2 | RAD51C | ENSPTRP00000009812 | ENSPTRP00000016062 | Breast cancer 2, early onset. | RAD51C isoform 1. | 0.994 |
| BRCA2 | RAD51D | ENSPTRP00000009812 | ENSPTRP00000078009 | Breast cancer 2, early onset. | RAD51D isoform 8. | 0.923 |
| BRCA2 | SLX1A | ENSPTRP00000009812 | ENSPTRP00000058845 | Breast cancer 2, early onset. | Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. | 0.699 |
| BRCA2 | WRN | ENSPTRP00000009812 | ENSPTRP00000091996 | Breast cancer 2, early onset. | WRN RecQ like helicase. | 0.933 |
| BRCA2 | XRCC2 | ENSPTRP00000009812 | ENSPTRP00000042785 | Breast cancer 2, early onset. | X-ray repair complementing defective repair in Chinese hamster cells 2. | 0.771 |
| BRCA2 | XRCC3 | ENSPTRP00000009812 | ENSPTRP00000011539 | Breast cancer 2, early onset. | DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily. | 0.978 |
| DMC1 | BRCA2 | ENSPTRP00000024757 | ENSPTRP00000009812 | Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily. | Breast cancer 2, early onset. | 0.951 |
| DMC1 | ENSPTRP00000070567 | ENSPTRP00000024757 | ENSPTRP00000070567 | Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily. | annotation not available | 0.794 |
| DMC1 | RAD51 | ENSPTRP00000024757 | ENSPTRP00000068995 | Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily. | DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] | 0.941 |
| DMC1 | RAD51B | ENSPTRP00000024757 | ENSPTRP00000081962 | Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily. | RAD51B isoform 1. | 0.807 |
| DMC1 | RAD51D | ENSPTRP00000024757 | ENSPTRP00000078009 | Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily. | RAD51D isoform 8. | 0.750 |
| DMC1 | SLX1A | ENSPTRP00000024757 | ENSPTRP00000058845 | Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily. | Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. | 0.497 |
| DMC1 | WRN | ENSPTRP00000024757 | ENSPTRP00000091996 | Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily. | WRN RecQ like helicase. | 0.854 |
| DMC1 | XRCC2 | ENSPTRP00000024757 | ENSPTRP00000042785 | Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily. | X-ray repair complementing defective repair in Chinese hamster cells 2. | 0.794 |
| DMC1 | XRCC3 | ENSPTRP00000024757 | ENSPTRP00000011539 | Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily. | DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily. | 0.904 |
| ENSPTRP00000070567 | BRCA2 | ENSPTRP00000070567 | ENSPTRP00000009812 | annotation not available | Breast cancer 2, early onset. | 0.771 |
