| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| APEX1 | MSH2 | ENSPTRP00000010344 | ENSPTRP00000066383 | DNA-(apurinic or apyrimidinic site) lyase, mitochondrial; Multifunctional protein that plays a central role in the cellular response to oxidative stress. The two major activities of APEX1 are DNA repair and redox regulation of transcriptional factors. Functions as a apurinic/apyrimidinic (AP) endodeoxyribonuclease in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents. Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break w [...] | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). | 0.469 |
| APEX1 | MUTYH | ENSPTRP00000010344 | ENSPTRP00000074478 | DNA-(apurinic or apyrimidinic site) lyase, mitochondrial; Multifunctional protein that plays a central role in the cellular response to oxidative stress. The two major activities of APEX1 are DNA repair and redox regulation of transcriptional factors. Functions as a apurinic/apyrimidinic (AP) endodeoxyribonuclease in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents. Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break w [...] | Adenine DNA glycosylase; Adenine glycosylase active on G-A mispairs. | 0.933 |
| APEX1 | OGG1 | ENSPTRP00000010344 | ENSPTRP00000025166 | DNA-(apurinic or apyrimidinic site) lyase, mitochondrial; Multifunctional protein that plays a central role in the cellular response to oxidative stress. The two major activities of APEX1 are DNA repair and redox regulation of transcriptional factors. Functions as a apurinic/apyrimidinic (AP) endodeoxyribonuclease in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents. Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break w [...] | 8-oxoguanine DNA glycosylase. | 0.932 |
| APEX1 | PCNA | ENSPTRP00000010344 | ENSPTRP00000022674 | DNA-(apurinic or apyrimidinic site) lyase, mitochondrial; Multifunctional protein that plays a central role in the cellular response to oxidative stress. The two major activities of APEX1 are DNA repair and redox regulation of transcriptional factors. Functions as a apurinic/apyrimidinic (AP) endodeoxyribonuclease in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents. Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break w [...] | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. | 0.876 |
| APEX1 | POLE | ENSPTRP00000010344 | ENSPTRP00000071830 | DNA-(apurinic or apyrimidinic site) lyase, mitochondrial; Multifunctional protein that plays a central role in the cellular response to oxidative stress. The two major activities of APEX1 are DNA repair and redox regulation of transcriptional factors. Functions as a apurinic/apyrimidinic (AP) endodeoxyribonuclease in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents. Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break w [...] | DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. | 0.712 |
| APEX1 | SPIB | ENSPTRP00000010344 | ENSPTRP00000066005 | DNA-(apurinic or apyrimidinic site) lyase, mitochondrial; Multifunctional protein that plays a central role in the cellular response to oxidative stress. The two major activities of APEX1 are DNA repair and redox regulation of transcriptional factors. Functions as a apurinic/apyrimidinic (AP) endodeoxyribonuclease in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents. Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break w [...] | T0182711 isoform 1. | 0.884 |
| APEX2 | MUTYH | ENSPTRP00000037716 | ENSPTRP00000074478 | DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. | Adenine DNA glycosylase; Adenine glycosylase active on G-A mispairs. | 0.785 |
| APEX2 | OGG1 | ENSPTRP00000037716 | ENSPTRP00000025166 | DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. | 8-oxoguanine DNA glycosylase. | 0.719 |
| APEX2 | PCNA | ENSPTRP00000037716 | ENSPTRP00000022674 | DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. | 0.810 |
| APEX2 | POLE | ENSPTRP00000037716 | ENSPTRP00000071830 | DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. | DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. | 0.573 |
| APEX2 | SPIB | ENSPTRP00000037716 | ENSPTRP00000066005 | DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. | T0182711 isoform 1. | 0.661 |
| HUS1-2 | MUTYH | ENSPTRP00000071453 | ENSPTRP00000074478 | HUS1 checkpoint clamp component. | Adenine DNA glycosylase; Adenine glycosylase active on G-A mispairs. | 0.741 |
| HUS1-2 | PCNA | ENSPTRP00000071453 | ENSPTRP00000022674 | HUS1 checkpoint clamp component. | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. | 0.483 |
| HUS1-2 | SPIB | ENSPTRP00000071453 | ENSPTRP00000066005 | HUS1 checkpoint clamp component. | T0182711 isoform 1. | 0.483 |
| MSH2 | APEX1 | ENSPTRP00000066383 | ENSPTRP00000010344 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). | DNA-(apurinic or apyrimidinic site) lyase, mitochondrial; Multifunctional protein that plays a central role in the cellular response to oxidative stress. The two major activities of APEX1 are DNA repair and redox regulation of transcriptional factors. Functions as a apurinic/apyrimidinic (AP) endodeoxyribonuclease in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents. Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break w [...] | 0.469 |
| MSH2 | MUTYH | ENSPTRP00000066383 | ENSPTRP00000074478 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). | Adenine DNA glycosylase; Adenine glycosylase active on G-A mispairs. | 0.823 |
| MSH2 | OGG1 | ENSPTRP00000066383 | ENSPTRP00000025166 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). | 8-oxoguanine DNA glycosylase. | 0.637 |
| MSH2 | PCNA | ENSPTRP00000066383 | ENSPTRP00000022674 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. | 0.946 |
| MSH2 | POLE | ENSPTRP00000066383 | ENSPTRP00000071830 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). | DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. | 0.898 |
| MSH2 | SPIB | ENSPTRP00000066383 | ENSPTRP00000066005 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). | T0182711 isoform 1. | 0.887 |
