STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ARHGEF6Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6. (783 aa)    
Predicted Functional Partners:
GIT1
G protein-coupled receptor kinase interacting ArfGAP 1.
    
 0.999
PAK1
Non-specific serine/threonine protein kinase.
    
 0.998
PAK3
Serine/threonine-protein kinase PAK 3; Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, or cell cycle regulation. Plays a role in dendrite spine morphogenesis as well as synapse formation and plasticity. Acts as downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates MAPK4 and MAPK6 and activates the downstrea [...]
    
 0.995
GIT2
G protein-coupled receptor kinase interacting ArfGAP 2.
    
 0.991
PARVB
Beta-parvin isoform X1.
   
 0.983
PAK5
Non-specific serine/threonine protein kinase.
    
 0.977
PAK4
Non-specific serine/threonine protein kinase.
    
 0.973
PAK6
Non-specific serine/threonine protein kinase.
    
 0.959
ARHGEF1
Rho guanine nucleotide exchange factor 1.
    
 0.940
ARHGEF12
Rho guanine nucleotide exchange factor (GEF) 12.
    
 0.938
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.