STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
XRCC6-2X-ray repair complementing defective repair in Chinese hamster cells 6. (609 aa)    
Predicted Functional Partners:
XRCC5
X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family.
  
 0.998
LIG4
DNA ligase.
   
 0.965
PRKDC
Protein kinase, DNA-activated, catalytic polypeptide; Belongs to the PI3/PI4-kinase family.
    
 0.962
DCLRE1C
DCLRE1C isoform 2.
   
 0.946
NHEJ1
Non-homologous end joining factor 1.
    
 0.936
WRN
WRN RecQ like helicase.
   
 
 0.934
APLF
Aprataxin and PNK-like factor isoform X1.
    
 
 0.900
PARP1
Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair.
   
 
 0.888
H2AFX
H2AFX isoform 1.
    
 0.869
LIG3
DNA ligase.
   
 0.862
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.