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The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
MAP3K5Mitogen-activated protein kinase kinase kinase 5. (1374 aa)    
Predicted Functional Partners:
TXN
Thioredoxin; Belongs to the thioredoxin family.
    
 0.997
MAP2K4
Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily.
   
0.996
DAXX
Death domain associated protein.
    
 0.996
MAP2K6
Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily.
   
0.995
ERN1
Endoplasmic reticulum to nucleus signaling 1.
   
0.990
DAB2IP
DAB2 interacting protein.
    
 0.988
ENSPTRP00000061486
Dual specificity mitogen-activated protein kinase kinase 3 isoform X1.
   
 0.984
TRAF2
TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.
   
 0.979
PARK7
PARK7 isoform 1.
    
 0.973
AKT1
AKT1 isoform 3; Belongs to the protein kinase superfamily.
    
0.964
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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