| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| BRIX1 | BYSL | ENSPTRP00000028781 | ENSPTRP00000063749 | BRX1, biogenesis of ribosomes, homolog. | BYSL isoform 1. | 0.942 |
| BRIX1 | ESF1 | ENSPTRP00000028781 | ENSPTRP00000022741 | BRX1, biogenesis of ribosomes, homolog. | ESF1, nucleolar pre-rRNA processing protein, homolog. | 0.851 |
| BRIX1 | IMP4 | ENSPTRP00000028781 | ENSPTRP00000021316 | BRX1, biogenesis of ribosomes, homolog. | IMP4, U3 small nucleolar ribonucleoprotein, homolog. | 0.924 |
| BRIX1 | LOC457357 | ENSPTRP00000028781 | ENSPTRP00000024905 | BRX1, biogenesis of ribosomes, homolog. | Ribosomal RNA processing 7 homolog A. | 0.847 |
| BRIX1 | RRP8 | ENSPTRP00000028781 | ENSPTRP00000005772 | BRX1, biogenesis of ribosomes, homolog. | Ribosomal RNA-processing protein 8; Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone- modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and pr [...] | 0.943 |
| BRIX1 | SPOUT1 | ENSPTRP00000028781 | ENSPTRP00000043336 | BRX1, biogenesis of ribosomes, homolog. | SPOUT domain containing methyltransferase 1. | 0.685 |
| BRIX1 | UTP11 | ENSPTRP00000028781 | ENSPTRP00000000982 | BRX1, biogenesis of ribosomes, homolog. | U3 small nucleolar RNA-associated protein 11; Involved in nucleolar processing of pre-18S ribosomal RNA. | 0.893 |
| BRIX1 | WDR36 | ENSPTRP00000028781 | ENSPTRP00000029316 | BRX1, biogenesis of ribosomes, homolog. | WD repeat domain 36. | 0.852 |
| BRIX1 | WDR46 | ENSPTRP00000028781 | ENSPTRP00000030811 | BRX1, biogenesis of ribosomes, homolog. | WD repeat domain 46. | 0.857 |
| BYSL | BRIX1 | ENSPTRP00000063749 | ENSPTRP00000028781 | BYSL isoform 1. | BRX1, biogenesis of ribosomes, homolog. | 0.942 |
| BYSL | ESF1 | ENSPTRP00000063749 | ENSPTRP00000022741 | BYSL isoform 1. | ESF1, nucleolar pre-rRNA processing protein, homolog. | 0.956 |
| BYSL | IMP4 | ENSPTRP00000063749 | ENSPTRP00000021316 | BYSL isoform 1. | IMP4, U3 small nucleolar ribonucleoprotein, homolog. | 0.968 |
| BYSL | LOC457357 | ENSPTRP00000063749 | ENSPTRP00000024905 | BYSL isoform 1. | Ribosomal RNA processing 7 homolog A. | 0.961 |
| BYSL | RRP8 | ENSPTRP00000063749 | ENSPTRP00000005772 | BYSL isoform 1. | Ribosomal RNA-processing protein 8; Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone- modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and pr [...] | 0.941 |
| BYSL | SPOUT1 | ENSPTRP00000063749 | ENSPTRP00000043336 | BYSL isoform 1. | SPOUT domain containing methyltransferase 1. | 0.661 |
| BYSL | UTP11 | ENSPTRP00000063749 | ENSPTRP00000000982 | BYSL isoform 1. | U3 small nucleolar RNA-associated protein 11; Involved in nucleolar processing of pre-18S ribosomal RNA. | 0.963 |
| BYSL | WDR36 | ENSPTRP00000063749 | ENSPTRP00000029316 | BYSL isoform 1. | WD repeat domain 36. | 0.961 |
| BYSL | WDR46 | ENSPTRP00000063749 | ENSPTRP00000030811 | BYSL isoform 1. | WD repeat domain 46. | 0.972 |
| ESF1 | BRIX1 | ENSPTRP00000022741 | ENSPTRP00000028781 | ESF1, nucleolar pre-rRNA processing protein, homolog. | BRX1, biogenesis of ribosomes, homolog. | 0.851 |
| ESF1 | BYSL | ENSPTRP00000022741 | ENSPTRP00000063749 | ESF1, nucleolar pre-rRNA processing protein, homolog. | BYSL isoform 1. | 0.956 |
