| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CUL3 | CUL5 | ENSPTRP00000022190 | ENSPTRP00000007307 | CUL3 isoform 2; Belongs to the cullin family. | CUL5 isoform 1; Belongs to the cullin family. | 0.687 |
| CUL3 | ENSPTRP00000084393 | ENSPTRP00000022190 | ENSPTRP00000084393 | CUL3 isoform 2; Belongs to the cullin family. | annotation not available | 0.954 |
| CUL3 | ENSPTRP00000084627 | ENSPTRP00000022190 | ENSPTRP00000084627 | CUL3 isoform 2; Belongs to the cullin family. | annotation not available | 0.802 |
| CUL3 | NAE1 | ENSPTRP00000022190 | ENSPTRP00000091978 | CUL3 isoform 2; Belongs to the cullin family. | NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Belongs to the ubiquitin-activating E1 family. ULA1 subfamily. | 0.749 |
| CUL3 | NEDD8 | ENSPTRP00000022190 | ENSPTRP00000090523 | CUL3 isoform 2; Belongs to the cullin family. | Ubiquitin-like protein Nedd8. | 0.967 |
| CUL3 | RBX1 | ENSPTRP00000022190 | ENSPTRP00000024839 | CUL3 isoform 2; Belongs to the cullin family. | Ring-box 1, E3 ubiquitin protein ligase. | 0.998 |
| CUL3 | UBA3 | ENSPTRP00000022190 | ENSPTRP00000043591 | CUL3 isoform 2; Belongs to the cullin family. | Ubiquitin-like modifier-activating enzyme 3. | 0.887 |
| CUL3 | UBE2F | ENSPTRP00000022190 | ENSPTRP00000087042 | CUL3 isoform 2; Belongs to the cullin family. | Ubiquitin conjugating enzyme E2 F (putative); Belongs to the ubiquitin-conjugating enzyme family. | 0.802 |
| CUL3 | UBE2M | ENSPTRP00000022190 | ENSPTRP00000048453 | CUL3 isoform 2; Belongs to the cullin family. | Ubiquitin conjugating enzyme E2 M; Belongs to the ubiquitin-conjugating enzyme family. | 0.921 |
| CUL5 | CUL3 | ENSPTRP00000007307 | ENSPTRP00000022190 | CUL5 isoform 1; Belongs to the cullin family. | CUL3 isoform 2; Belongs to the cullin family. | 0.687 |
| CUL5 | ENSPTRP00000084393 | ENSPTRP00000007307 | ENSPTRP00000084393 | CUL5 isoform 1; Belongs to the cullin family. | annotation not available | 0.945 |
| CUL5 | ENSPTRP00000084627 | ENSPTRP00000007307 | ENSPTRP00000084627 | CUL5 isoform 1; Belongs to the cullin family. | annotation not available | 0.898 |
| CUL5 | NAE1 | ENSPTRP00000007307 | ENSPTRP00000091978 | CUL5 isoform 1; Belongs to the cullin family. | NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Belongs to the ubiquitin-activating E1 family. ULA1 subfamily. | 0.746 |
| CUL5 | NEDD8 | ENSPTRP00000007307 | ENSPTRP00000090523 | CUL5 isoform 1; Belongs to the cullin family. | Ubiquitin-like protein Nedd8. | 0.966 |
| CUL5 | RBX1 | ENSPTRP00000007307 | ENSPTRP00000024839 | CUL5 isoform 1; Belongs to the cullin family. | Ring-box 1, E3 ubiquitin protein ligase. | 0.999 |
| CUL5 | UBA3 | ENSPTRP00000007307 | ENSPTRP00000043591 | CUL5 isoform 1; Belongs to the cullin family. | Ubiquitin-like modifier-activating enzyme 3. | 0.920 |
| CUL5 | UBE2F | ENSPTRP00000007307 | ENSPTRP00000087042 | CUL5 isoform 1; Belongs to the cullin family. | Ubiquitin conjugating enzyme E2 F (putative); Belongs to the ubiquitin-conjugating enzyme family. | 0.930 |
| CUL5 | UBE2M | ENSPTRP00000007307 | ENSPTRP00000048453 | CUL5 isoform 1; Belongs to the cullin family. | Ubiquitin conjugating enzyme E2 M; Belongs to the ubiquitin-conjugating enzyme family. | 0.874 |
| ENSPTRP00000084393 | CUL3 | ENSPTRP00000084393 | ENSPTRP00000022190 | annotation not available | CUL3 isoform 2; Belongs to the cullin family. | 0.954 |
| ENSPTRP00000084393 | CUL5 | ENSPTRP00000084393 | ENSPTRP00000007307 | annotation not available | CUL5 isoform 1; Belongs to the cullin family. | 0.945 |
