OPRM1 protein (Pan troglodytes) - STRING interaction network

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OPRM1

Mu-type opioid receptor; Receptor for endogenous opioids such as beta-endorphin and endomorphin. Receptor for natural and synthetic opioids including morphine, heroin, DAMGO, fentanyl, etorphine, buprenorphin and methadone. Agonist binding to the receptor induces coupling to an inactive GDP-bound heterotrimeric G-protein complex and subsequent exchange of GDP for GTP in the G-protein alpha subunit leading to dissociation of the G-protein complex with the free GTP-bound G-protein alpha and the G-protein beta-gamma dimer activating downstream cellular effectors. The agonist- and cell typ [...] (476 aa)

Predicted Functional Partners:

PENK

0.999

POMC

0.999

PDYN

0.989

GNAI1

0.983

ARRB2

0.971

ARRB1

0.970

GNAI3

0.947

GNAO1

0.946

GNG2

0.945

GNB1

0.943

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARRB1	ARRB2	ENSPTRP00000043134	ENSPTRP00000014687	ARRB1 isoform 1.	ARRB2 isoform 2.	0.981
ARRB1	GNAI1	ENSPTRP00000043134	ENSPTRP00000071974	ARRB1 isoform 1.	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1.	0.412
ARRB1	GNAO1	ENSPTRP00000043134	ENSPTRP00000088044	ARRB1 isoform 1.	G protein subunit alpha o1.	0.408
ARRB1	GNB1	ENSPTRP00000043134	ENSPTRP00000067330	ARRB1 isoform 1.	Guanine nucleotide binding protein (G protein), beta polypeptide 1.	0.462
ARRB1	OPRM1	ENSPTRP00000043134	ENSPTRP00000043686	ARRB1 isoform 1.	Mu-type opioid receptor; Receptor for endogenous opioids such as beta-endorphin and endomorphin. Receptor for natural and synthetic opioids including morphine, heroin, DAMGO, fentanyl, etorphine, buprenorphin and methadone. Agonist binding to the receptor induces coupling to an inactive GDP-bound heterotrimeric G-protein complex and subsequent exchange of GDP for GTP in the G-protein alpha subunit leading to dissociation of the G-protein complex with the free GTP-bound G-protein alpha and the G-protein beta-gamma dimer activating downstream cellular effectors. The agonist- and cell typ [...]	0.970
ARRB2	ARRB1	ENSPTRP00000014687	ENSPTRP00000043134	ARRB2 isoform 2.	ARRB1 isoform 1.	0.981
ARRB2	GNAO1	ENSPTRP00000014687	ENSPTRP00000088044	ARRB2 isoform 2.	G protein subunit alpha o1.	0.409
ARRB2	OPRM1	ENSPTRP00000014687	ENSPTRP00000043686	ARRB2 isoform 2.	Mu-type opioid receptor; Receptor for endogenous opioids such as beta-endorphin and endomorphin. Receptor for natural and synthetic opioids including morphine, heroin, DAMGO, fentanyl, etorphine, buprenorphin and methadone. Agonist binding to the receptor induces coupling to an inactive GDP-bound heterotrimeric G-protein complex and subsequent exchange of GDP for GTP in the G-protein alpha subunit leading to dissociation of the G-protein complex with the free GTP-bound G-protein alpha and the G-protein beta-gamma dimer activating downstream cellular effectors. The agonist- and cell typ [...]	0.971
GNAI1	ARRB1	ENSPTRP00000071974	ENSPTRP00000043134	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1.	ARRB1 isoform 1.	0.412
GNAI1	GNAI3	ENSPTRP00000071974	ENSPTRP00000001821	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1.	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3.	0.985
GNAI1	GNAO1	ENSPTRP00000071974	ENSPTRP00000088044	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1.	G protein subunit alpha o1.	0.823
GNAI1	GNB1	ENSPTRP00000071974	ENSPTRP00000067330	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1.	Guanine nucleotide binding protein (G protein), beta polypeptide 1.	0.998
GNAI1	GNG2	ENSPTRP00000071974	ENSPTRP00000065345	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.995
GNAI1	OPRM1	ENSPTRP00000071974	ENSPTRP00000043686	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1.	Mu-type opioid receptor; Receptor for endogenous opioids such as beta-endorphin and endomorphin. Receptor for natural and synthetic opioids including morphine, heroin, DAMGO, fentanyl, etorphine, buprenorphin and methadone. Agonist binding to the receptor induces coupling to an inactive GDP-bound heterotrimeric G-protein complex and subsequent exchange of GDP for GTP in the G-protein alpha subunit leading to dissociation of the G-protein complex with the free GTP-bound G-protein alpha and the G-protein beta-gamma dimer activating downstream cellular effectors. The agonist- and cell typ [...]	0.983
GNAI1	POMC	ENSPTRP00000071974	ENSPTRP00000052139	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1.	Proopiomelanocortin.	0.774
GNAI3	GNAI1	ENSPTRP00000001821	ENSPTRP00000071974	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3.	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1.	0.985
GNAI3	GNAO1	ENSPTRP00000001821	ENSPTRP00000088044	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3.	G protein subunit alpha o1.	0.821
GNAI3	GNB1	ENSPTRP00000001821	ENSPTRP00000067330	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3.	Guanine nucleotide binding protein (G protein), beta polypeptide 1.	0.996
GNAI3	GNG2	ENSPTRP00000001821	ENSPTRP00000065345	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.945
GNAI3	OPRM1	ENSPTRP00000001821	ENSPTRP00000043686	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3.	Mu-type opioid receptor; Receptor for endogenous opioids such as beta-endorphin and endomorphin. Receptor for natural and synthetic opioids including morphine, heroin, DAMGO, fentanyl, etorphine, buprenorphin and methadone. Agonist binding to the receptor induces coupling to an inactive GDP-bound heterotrimeric G-protein complex and subsequent exchange of GDP for GTP in the G-protein alpha subunit leading to dissociation of the G-protein complex with the free GTP-bound G-protein alpha and the G-protein beta-gamma dimer activating downstream cellular effectors. The agonist- and cell typ [...]	0.947

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