| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ACACA | ACLY | ENSPTRP00000074254 | ENSPTRP00000044752 | Acetyl-CoA carboxylase alpha. | ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family. | 0.959 |
| ACACA | CS | ENSPTRP00000074254 | ENSPTRP00000008664 | Acetyl-CoA carboxylase alpha. | Citrate synthase, mitochondrial isoform X1. | 0.881 |
| ACACA | DLAT | ENSPTRP00000074254 | ENSPTRP00000007349 | Acetyl-CoA carboxylase alpha. | Acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | 0.921 |
| ACACA | FASN | ENSPTRP00000074254 | ENSPTRP00000016660 | Acetyl-CoA carboxylase alpha. | Fatty acid synthase. | 0.991 |
| ACACA | MDH1 | ENSPTRP00000074254 | ENSPTRP00000088176 | Acetyl-CoA carboxylase alpha. | Malate dehydrogenase. | 0.569 |
| ACACA | PC | ENSPTRP00000074254 | ENSPTRP00000045149 | Acetyl-CoA carboxylase alpha. | Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. | 0.627 |
| ACACA | SUCLG1 | ENSPTRP00000074254 | ENSPTRP00000020798 | Acetyl-CoA carboxylase alpha. | Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits. | 0.825 |
| ACLY | ACACA | ENSPTRP00000044752 | ENSPTRP00000074254 | ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family. | Acetyl-CoA carboxylase alpha. | 0.959 |
| ACLY | ACO1 | ENSPTRP00000044752 | ENSPTRP00000035646 | ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family. | Aconitase 1, soluble; Belongs to the aconitase/IPM isomerase family. | 0.964 |
| ACLY | ACO2 | ENSPTRP00000044752 | ENSPTRP00000024853 | ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family. | ACO2 isoform 2. | 0.964 |
| ACLY | CS | ENSPTRP00000044752 | ENSPTRP00000008664 | ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family. | Citrate synthase, mitochondrial isoform X1. | 0.983 |
| ACLY | DLAT | ENSPTRP00000044752 | ENSPTRP00000007349 | ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family. | Acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | 0.982 |
| ACLY | FASN | ENSPTRP00000044752 | ENSPTRP00000016660 | ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family. | Fatty acid synthase. | 0.988 |
| ACLY | MDH1 | ENSPTRP00000044752 | ENSPTRP00000088176 | ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family. | Malate dehydrogenase. | 0.968 |
| ACLY | MDH2 | ENSPTRP00000044752 | ENSPTRP00000033039 | ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family. | Malate dehydrogenase. | 0.962 |
| ACLY | PC | ENSPTRP00000044752 | ENSPTRP00000045149 | ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family. | Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. | 0.946 |
| ACLY | SUCLG1 | ENSPTRP00000044752 | ENSPTRP00000020798 | ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family. | Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits. | 0.960 |
| ACO1 | ACLY | ENSPTRP00000035646 | ENSPTRP00000044752 | Aconitase 1, soluble; Belongs to the aconitase/IPM isomerase family. | ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family. | 0.964 |
| ACO1 | ACO2 | ENSPTRP00000035646 | ENSPTRP00000024853 | Aconitase 1, soluble; Belongs to the aconitase/IPM isomerase family. | ACO2 isoform 2. | 0.933 |
| ACO1 | CS | ENSPTRP00000035646 | ENSPTRP00000008664 | Aconitase 1, soluble; Belongs to the aconitase/IPM isomerase family. | Citrate synthase, mitochondrial isoform X1. | 0.988 |