ACLY protein (Pan troglodytes) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

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gene neighborhood

gene co-occurrence

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Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACACA	ACLY	ENSPTRP00000074254	ENSPTRP00000044752	Acetyl-CoA carboxylase alpha.	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	0.946
ACACA	CS	ENSPTRP00000074254	ENSPTRP00000008664	Acetyl-CoA carboxylase alpha.	Citrate synthase, mitochondrial isoform X1.	0.862
ACACA	DLAT	ENSPTRP00000074254	ENSPTRP00000007349	Acetyl-CoA carboxylase alpha.	Acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).	0.917
ACACA	FASN	ENSPTRP00000074254	ENSPTRP00000016660	Acetyl-CoA carboxylase alpha.	Fatty acid synthase.	0.989
ACACA	MDH1	ENSPTRP00000074254	ENSPTRP00000088176	Acetyl-CoA carboxylase alpha.	Malate dehydrogenase.	0.530
ACACA	PC	ENSPTRP00000074254	ENSPTRP00000045149	Acetyl-CoA carboxylase alpha.	Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.	0.656
ACLY	ACACA	ENSPTRP00000044752	ENSPTRP00000074254	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	Acetyl-CoA carboxylase alpha.	0.946
ACLY	ACO1	ENSPTRP00000044752	ENSPTRP00000035646	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	Aconitase 1, soluble; Belongs to the aconitase/IPM isomerase family.	0.967
ACLY	ACO2	ENSPTRP00000044752	ENSPTRP00000024853	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	ACO2 isoform 2.	0.966
ACLY	CS	ENSPTRP00000044752	ENSPTRP00000008664	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	Citrate synthase, mitochondrial isoform X1.	0.985
ACLY	DLAT	ENSPTRP00000044752	ENSPTRP00000007349	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	Acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).	0.982
ACLY	FASN	ENSPTRP00000044752	ENSPTRP00000016660	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	Fatty acid synthase.	0.991
ACLY	MDH1	ENSPTRP00000044752	ENSPTRP00000088176	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	Malate dehydrogenase.	0.966
ACLY	MDH2	ENSPTRP00000044752	ENSPTRP00000033039	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	Malate dehydrogenase.	0.959
ACLY	PC	ENSPTRP00000044752	ENSPTRP00000045149	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.	0.949
ACLY	PCK2	ENSPTRP00000044752	ENSPTRP00000010507	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	Phosphoenolpyruvate carboxykinase 2, mitochondrial.	0.941
ACO1	ACLY	ENSPTRP00000035646	ENSPTRP00000044752	Aconitase 1, soluble; Belongs to the aconitase/IPM isomerase family.	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	0.967
ACO1	ACO2	ENSPTRP00000035646	ENSPTRP00000024853	Aconitase 1, soluble; Belongs to the aconitase/IPM isomerase family.	ACO2 isoform 2.	0.937
ACO1	CS	ENSPTRP00000035646	ENSPTRP00000008664	Aconitase 1, soluble; Belongs to the aconitase/IPM isomerase family.	Citrate synthase, mitochondrial isoform X1.	0.986
ACO1	DLAT	ENSPTRP00000035646	ENSPTRP00000007349	Aconitase 1, soluble; Belongs to the aconitase/IPM isomerase family.	Acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).	0.542