| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AKR1C3 | AKR1C4 | ENSPTRP00000078798 | ENSPTRP00000003803 | Aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II). | Aldo-keto reductase family 1 member C4. | 0.999 |
| AKR1C3 | CYP17A1 | ENSPTRP00000078798 | ENSPTRP00000069568 | Aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II). | Steroid 17-alpha-hydroxylase/17,20 lyase; A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol. Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, [...] | 0.945 |
| AKR1C3 | HSD17B11 | ENSPTRP00000078798 | ENSPTRP00000044863 | Aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II). | Hydroxysteroid (17-beta) dehydrogenase 11; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.913 |
| AKR1C3 | HSD17B3 | ENSPTRP00000078798 | ENSPTRP00000073561 | Aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II). | Hydroxysteroid 17-beta dehydrogenase 3; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.947 |
| AKR1C3 | LOC746545 | ENSPTRP00000078798 | ENSPTRP00000003813 | Aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II). | Aldo-keto reductase family 1 member C3. | 0.901 |
| AKR1C3 | UGT1A5 | ENSPTRP00000078798 | ENSPTRP00000063403 | Aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II). | UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. | 0.909 |
| AKR1C3 | UGT2A3 | ENSPTRP00000078798 | ENSPTRP00000053491 | Aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II). | UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. | 0.911 |
| AKR1C3 | UGT2B10 | ENSPTRP00000078798 | ENSPTRP00000072985 | Aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II). | UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. | 0.910 |
| AKR1C3 | UGT2B4 | ENSPTRP00000078798 | ENSPTRP00000027702 | Aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II). | UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. | 0.910 |
| AKR1C3 | UGT2B7 | ENSPTRP00000078798 | ENSPTRP00000063599 | Aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II). | UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. | 0.910 |
| AKR1C4 | AKR1C3 | ENSPTRP00000003803 | ENSPTRP00000078798 | Aldo-keto reductase family 1 member C4. | Aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II). | 0.999 |
| AKR1C4 | CYP17A1 | ENSPTRP00000003803 | ENSPTRP00000069568 | Aldo-keto reductase family 1 member C4. | Steroid 17-alpha-hydroxylase/17,20 lyase; A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol. Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, [...] | 0.918 |
| AKR1C4 | HSD17B11 | ENSPTRP00000003803 | ENSPTRP00000044863 | Aldo-keto reductase family 1 member C4. | Hydroxysteroid (17-beta) dehydrogenase 11; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.910 |
| AKR1C4 | HSD17B3 | ENSPTRP00000003803 | ENSPTRP00000073561 | Aldo-keto reductase family 1 member C4. | Hydroxysteroid 17-beta dehydrogenase 3; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.928 |
| AKR1C4 | LOC746545 | ENSPTRP00000003803 | ENSPTRP00000003813 | Aldo-keto reductase family 1 member C4. | Aldo-keto reductase family 1 member C3. | 0.901 |
| AKR1C4 | UGT1A5 | ENSPTRP00000003803 | ENSPTRP00000063403 | Aldo-keto reductase family 1 member C4. | UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. | 0.909 |
| AKR1C4 | UGT2A3 | ENSPTRP00000003803 | ENSPTRP00000053491 | Aldo-keto reductase family 1 member C4. | UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. | 0.910 |
| AKR1C4 | UGT2B10 | ENSPTRP00000003803 | ENSPTRP00000072985 | Aldo-keto reductase family 1 member C4. | UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. | 0.910 |
| AKR1C4 | UGT2B4 | ENSPTRP00000003803 | ENSPTRP00000027702 | Aldo-keto reductase family 1 member C4. | UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. | 0.910 |
| AKR1C4 | UGT2B7 | ENSPTRP00000003803 | ENSPTRP00000063599 | Aldo-keto reductase family 1 member C4. | UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. | 0.910 |
