Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
RTN1Reticulon-1; May be involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells. (776 aa)    
Predicted Functional Partners:
MANF
MANF isoform 1.
   
 
 0.862
VSNL1
VSNL1 isoform 1.
   
  
 0.854
RTN4
Reticulon.
    
 
 0.839
MAPT
Microtubule-associated protein tau; Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabili [...]
   
 
 0.813
ENSPTRP00000086254
Microtubule-associated protein tau.
   
 
 0.813
ATN1
Atrophin-1; Transcriptional corepressor. Corepressor of MTG8 transcriptional repression. Recruits NR2E1 to repress transcription. Has some intrinsic repression activity. Promotes vascular smooth cell (VSMC) migration and orientation (By similarity).
      
 0.770
LRCH1
Leucine rich repeats and calponin homology domain containing 1.
    
 0.762
PXT1
Peroxisomal testis enriched protein 1.
      
 0.752
LRP10
Low density lipoprotein receptor-related protein 10.
   
  
 0.718
LINGO1
Leucine rich repeat and Ig domain containing 1.
   
 0.716
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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