Export your current network:
... as a vector graphic:
SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc
... as short tabular text output:
TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)
... as tabular text output:
TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)
... as an XML summary:
structured XML interaction data, according to the 'PSI-MI' data standard
... protein node degrees:
node degree of proteins in your network (given the current score cut-off)
... network coordinates:
a flat-file format describing the coordinates and colors of nodes in the network
... protein sequences:
MFA: multi-fasta format - containing the aminoacid sequences in the network
... protein annotations:
a tab-delimited file describing the names, domains and descriptions of proteins in your network
... functional annotations:
a tab-delimited file containing all known functional terms of proteins in your network
Browse interactions in tabular form:
| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| BARD1 | BRCA1 | ENSPTRP00000075471 | ENSPTRP00000070120 | BRCA1 associated RING domain 1. | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] | 0.999 |
| BARD1 | RTEL1-4 | ENSPTRP00000075471 | ENSPTRP00000076045 | BRCA1 associated RING domain 1. | Regulator of telomere elongation helicase 1. | 0.768 |
| BARD1 | SLF1 | ENSPTRP00000075471 | ENSPTRP00000029231 | BRCA1 associated RING domain 1. | SLF1 isoform 2. | 0.965 |
| BARD1 | SLX4 | ENSPTRP00000075471 | ENSPTRP00000013163 | BRCA1 associated RING domain 1. | SLX4 structure-specific endonuclease subunit. | 0.616 |
| BARD1 | TOPBP1 | ENSPTRP00000075471 | ENSPTRP00000026557 | BRCA1 associated RING domain 1. | Topoisomerase (DNA) II binding protein 1. | 0.997 |
| BARD1 | WRN | ENSPTRP00000075471 | ENSPTRP00000091996 | BRCA1 associated RING domain 1. | WRN RecQ like helicase. | 0.962 |
| BRCA1 | BARD1 | ENSPTRP00000070120 | ENSPTRP00000075471 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] | BRCA1 associated RING domain 1. | 0.999 |
| BRCA1 | ERCC3 | ENSPTRP00000070120 | ENSPTRP00000087351 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] | ERCC excision repair 3, TFIIH core complex helicase subunit. | 0.677 |
| BRCA1 | GTF2H4 | ENSPTRP00000070120 | ENSPTRP00000030616 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] | General transcription factor IIH subunit 4; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFII [...] | 0.472 |
| BRCA1 | RTEL1-4 | ENSPTRP00000070120 | ENSPTRP00000076045 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] | Regulator of telomere elongation helicase 1. | 0.823 |
| BRCA1 | SLF1 | ENSPTRP00000070120 | ENSPTRP00000029231 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] | SLF1 isoform 2. | 0.833 |
| BRCA1 | SLX4 | ENSPTRP00000070120 | ENSPTRP00000013163 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] | SLX4 structure-specific endonuclease subunit. | 0.827 |
| BRCA1 | TOPBP1 | ENSPTRP00000070120 | ENSPTRP00000026557 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] | Topoisomerase (DNA) II binding protein 1. | 0.998 |
| BRCA1 | WRN | ENSPTRP00000070120 | ENSPTRP00000091996 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] | WRN RecQ like helicase. | 0.966 |
| ERCC3 | BRCA1 | ENSPTRP00000087351 | ENSPTRP00000070120 | ERCC excision repair 3, TFIIH core complex helicase subunit. | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] | 0.677 |
| ERCC3 | GTF2H2C | ENSPTRP00000087351 | ENSPTRP00000029040 | ERCC excision repair 3, TFIIH core complex helicase subunit. | General transcription factor IIH subunit. | 0.996 |
| ERCC3 | GTF2H4 | ENSPTRP00000087351 | ENSPTRP00000030616 | ERCC excision repair 3, TFIIH core complex helicase subunit. | General transcription factor IIH subunit 4; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFII [...] | 0.999 |
| ERCC3 | MMS19 | ENSPTRP00000087351 | ENSPTRP00000004925 | ERCC excision repair 3, TFIIH core complex helicase subunit. | MMS19 isoform 2. | 0.884 |
| ERCC3 | RTEL1-4 | ENSPTRP00000087351 | ENSPTRP00000076045 | ERCC excision repair 3, TFIIH core complex helicase subunit. | Regulator of telomere elongation helicase 1. | 0.755 |
| ERCC3 | SLX4 | ENSPTRP00000087351 | ENSPTRP00000013163 | ERCC excision repair 3, TFIIH core complex helicase subunit. | SLX4 structure-specific endonuclease subunit. | 0.514 |
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