STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
NLGN4YNeuroligin 4 Y-linked. (873 aa)    
Predicted Functional Partners:
NRXN2
NRXN2 isoform 2.
   
 0.998
NRXN1
NRXN1 isoform 9.
   
 0.979
ZFY
Zinc finger Y-chromosomal protein; Probable transcriptional activator. Binds to the consensus sequence 5'-AGGCCY-3' (By similarity).
   
 0.943
USP9Y
USP9Y isoform 1; Belongs to the peptidase C19 family.
   
  
 0.932
UTY
Histone demethylase UTY; Male-specific histone demethylase that catalyzes trimethylated 'Lys-27' (H3K27me3) demethylation in histone H3. Has relatively low lysine demethylase activity.
   
 
 0.899
DLG4
Discs large MAGUK scaffold protein 4; Belongs to the MAGUK family.
   
 0.895
SRY
Sex-determining region Y protein; Transcriptional regulator that controls a genetic switch in male development. It is responsible for initiating male sex determination. SRY HMG box recognizes DNA by partial intercalation in the minor groove. Promotes DNA bending (By similarity).
   
 
 0.887
RPS4Y2
40S ribosomal protein S4, Y isoform 2; Belongs to the eukaryotic ribosomal protein eS4 family.
   
 
 0.866
PRKX
Protein kinase, X-linked; Belongs to the protein kinase superfamily.
   
 
 0.810
PRKY
Serine/threonine-protein kinase PRKX.
   
 
 0.806
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.