| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ENSPTRP00000090482 | OTUB1 | ENSPTRP00000090482 | ENSPTRP00000074741 | annotation not available | OTUB1 isoform 1. | 0.631 |
| ENSPTRP00000090482 | RNF168 | ENSPTRP00000090482 | ENSPTRP00000086137 | annotation not available | E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...] | 0.734 |
| ENSPTRP00000090482 | RNF8 | ENSPTRP00000090482 | ENSPTRP00000057853 | annotation not available | E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] | 0.746 |
| ENSPTRP00000090482 | TRAF6 | ENSPTRP00000090482 | ENSPTRP00000006096 | annotation not available | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. | 0.459 |
| ENSPTRP00000090482 | UBA1 | ENSPTRP00000090482 | ENSPTRP00000065814 | annotation not available | UBA1 isoform 3; Belongs to the ubiquitin-activating E1 family. | 0.617 |
| ENSPTRP00000090482 | UBE2N | ENSPTRP00000090482 | ENSPTRP00000009000 | annotation not available | Ubiquitin conjugating enzyme E2 N; Belongs to the ubiquitin-conjugating enzyme family. | 0.928 |
| ENSPTRP00000090482 | UBE2NL | ENSPTRP00000090482 | ENSPTRP00000047232 | annotation not available | Ubiquitin conjugating enzyme E2 N like (gene/pseudogene). | 0.893 |
| ENSPTRP00000090482 | UBE2V1 | ENSPTRP00000090482 | ENSPTRP00000080171 | annotation not available | UBE2V2 isoform 7. | 0.995 |
| ENSPTRP00000090482 | UBE2V1-2 | ENSPTRP00000090482 | ENSPTRP00000059656 | annotation not available | Ubiquitin-conjugating enzyme E2 variant 1. | 0.901 |
| OTUB1 | ENSPTRP00000090482 | ENSPTRP00000074741 | ENSPTRP00000090482 | OTUB1 isoform 1. | annotation not available | 0.631 |
| OTUB1 | RNF168 | ENSPTRP00000074741 | ENSPTRP00000086137 | OTUB1 isoform 1. | E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...] | 0.608 |
| OTUB1 | TRAF6 | ENSPTRP00000074741 | ENSPTRP00000006096 | OTUB1 isoform 1. | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. | 0.912 |
| OTUB1 | UBA1 | ENSPTRP00000074741 | ENSPTRP00000065814 | OTUB1 isoform 1. | UBA1 isoform 3; Belongs to the ubiquitin-activating E1 family. | 0.473 |
| OTUB1 | UBE2N | ENSPTRP00000074741 | ENSPTRP00000009000 | OTUB1 isoform 1. | Ubiquitin conjugating enzyme E2 N; Belongs to the ubiquitin-conjugating enzyme family. | 0.861 |
| OTUB1 | UBE2NL | ENSPTRP00000074741 | ENSPTRP00000047232 | OTUB1 isoform 1. | Ubiquitin conjugating enzyme E2 N like (gene/pseudogene). | 0.861 |
| OTUB1 | UBE2V2 | ENSPTRP00000074741 | ENSPTRP00000080565 | OTUB1 isoform 1. | Ubiquitin-conjugating enzyme E2 variant 2. | 0.718 |
| RNF168 | ENSPTRP00000090482 | ENSPTRP00000086137 | ENSPTRP00000090482 | E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...] | annotation not available | 0.734 |
| RNF168 | OTUB1 | ENSPTRP00000086137 | ENSPTRP00000074741 | E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...] | OTUB1 isoform 1. | 0.608 |
| RNF168 | RNF8 | ENSPTRP00000086137 | ENSPTRP00000057853 | E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...] | E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] | 0.892 |
| RNF168 | UBA1 | ENSPTRP00000086137 | ENSPTRP00000065814 | E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...] | UBA1 isoform 3; Belongs to the ubiquitin-activating E1 family. | 0.400 |
