PCDH19 protein (Pan troglodytes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

PCDH19

PCDH19 isoform 2. (1148 aa)

Predicted Functional Partners:

PAFAH1B1

0.841

DYNC1I1

0.781

UBE2K

0.734

DLGAP1

0.719

SCN1A

0.702

CDH2

0.679

KCNQ2

0.678

CDKL5

0.674

STXBP1

0.674

ATP1B1

0.673

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATP1B1	DLGAP1	ENSPTRP00000002750	ENSPTRP00000016750	Sodium/potassium-transporting ATPase subunit beta-1; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane (By similarity).	DLG associated protein 1.	0.441
ATP1B1	DYNC1I1	ENSPTRP00000002750	ENSPTRP00000033226	Sodium/potassium-transporting ATPase subunit beta-1; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane (By similarity).	Dynein cytoplasmic 1 intermediate chain 1.	0.665
ATP1B1	PAFAH1B1	ENSPTRP00000002750	ENSPTRP00000078363	Sodium/potassium-transporting ATPase subunit beta-1; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane (By similarity).	Platelet-activating factor acetylhydrolase IB subunit alpha; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ven [...]	0.709
ATP1B1	PCDH19	ENSPTRP00000002750	ENSPTRP00000047348	Sodium/potassium-transporting ATPase subunit beta-1; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane (By similarity).	PCDH19 isoform 2.	0.673
ATP1B1	UBE2K	ENSPTRP00000002750	ENSPTRP00000088110	Sodium/potassium-transporting ATPase subunit beta-1; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane (By similarity).	Ubiquitin-conjugating enzyme E2-25 kDa; Belongs to the ubiquitin-conjugating enzyme family.	0.767
CDH2	PCDH19	ENSPTRP00000092804	ENSPTRP00000047348	Cadherin 2, type 1, N-cadherin (Neuronal); Cadherins are calcium-dependent cell adhesion proteins.	PCDH19 isoform 2.	0.679
CDKL5	KCNQ2	ENSPTRP00000037200	ENSPTRP00000023658	Cyclin dependent kinase like 5.	KCNQ2 isoform 7; Belongs to the potassium channel family.	0.696
CDKL5	PCDH19	ENSPTRP00000037200	ENSPTRP00000047348	Cyclin dependent kinase like 5.	PCDH19 isoform 2.	0.674
CDKL5	SCN1A	ENSPTRP00000037200	ENSPTRP00000021517	Cyclin dependent kinase like 5.	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	0.752
CDKL5	STXBP1	ENSPTRP00000037200	ENSPTRP00000086703	Cyclin dependent kinase like 5.	Syntaxin binding protein 1; Belongs to the STXBP/unc-18/SEC1 family.	0.779
DLGAP1	ATP1B1	ENSPTRP00000016750	ENSPTRP00000002750	DLG associated protein 1.	Sodium/potassium-transporting ATPase subunit beta-1; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane (By similarity).	0.441
DLGAP1	DYNC1I1	ENSPTRP00000016750	ENSPTRP00000033226	DLG associated protein 1.	Dynein cytoplasmic 1 intermediate chain 1.	0.699
DLGAP1	PAFAH1B1	ENSPTRP00000016750	ENSPTRP00000078363	DLG associated protein 1.	Platelet-activating factor acetylhydrolase IB subunit alpha; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ven [...]	0.764
DLGAP1	PCDH19	ENSPTRP00000016750	ENSPTRP00000047348	DLG associated protein 1.	PCDH19 isoform 2.	0.719
DLGAP1	UBE2K	ENSPTRP00000016750	ENSPTRP00000088110	DLG associated protein 1.	Ubiquitin-conjugating enzyme E2-25 kDa; Belongs to the ubiquitin-conjugating enzyme family.	0.562
DYNC1I1	ATP1B1	ENSPTRP00000033226	ENSPTRP00000002750	Dynein cytoplasmic 1 intermediate chain 1.	Sodium/potassium-transporting ATPase subunit beta-1; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane (By similarity).	0.665
DYNC1I1	DLGAP1	ENSPTRP00000033226	ENSPTRP00000016750	Dynein cytoplasmic 1 intermediate chain 1.	DLG associated protein 1.	0.699
DYNC1I1	PAFAH1B1	ENSPTRP00000033226	ENSPTRP00000078363	Dynein cytoplasmic 1 intermediate chain 1.	Platelet-activating factor acetylhydrolase IB subunit alpha; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ven [...]	0.955
DYNC1I1	PCDH19	ENSPTRP00000033226	ENSPTRP00000047348	Dynein cytoplasmic 1 intermediate chain 1.	PCDH19 isoform 2.	0.781
DYNC1I1	UBE2K	ENSPTRP00000033226	ENSPTRP00000088110	Dynein cytoplasmic 1 intermediate chain 1.	Ubiquitin-conjugating enzyme E2-25 kDa; Belongs to the ubiquitin-conjugating enzyme family.	0.751