| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AR | NR0B1 | ENSPTRP00000076864 | ENSPTRP00000047467 | Androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3. | Nuclear receptor subfamily 0 group B member 1; Orphan nuclear receptor. Component of a cascade required for the development of the hypothalamic-pituitary-adrenal-gonadal axis. Acts as a coregulatory protein that inhibits the transcriptional activity of other nuclear receptors through heterodimeric interactions. May also have a role in the development of the embryo and in the maintenance of embryonic stem cell pluripotency (By similarity). Belongs to the nuclear hormone receptor family. NR0 subfamily. | 0.786 |
| AR | STAR | ENSPTRP00000076864 | ENSPTRP00000034528 | Androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3. | Steroidogenic acute regulatory protein, mitochondrial; Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone. | 0.556 |
| ENSPTRP00000071338 | ESRRB | ENSPTRP00000071338 | ENSPTRP00000064444 | annotation not available | Estrogen related receptor beta. | 0.639 |
| ENSPTRP00000071338 | NR0B1 | ENSPTRP00000071338 | ENSPTRP00000047467 | annotation not available | Nuclear receptor subfamily 0 group B member 1; Orphan nuclear receptor. Component of a cascade required for the development of the hypothalamic-pituitary-adrenal-gonadal axis. Acts as a coregulatory protein that inhibits the transcriptional activity of other nuclear receptors through heterodimeric interactions. May also have a role in the development of the embryo and in the maintenance of embryonic stem cell pluripotency (By similarity). Belongs to the nuclear hormone receptor family. NR0 subfamily. | 0.708 |
| ENSPTRP00000073411 | ESRRB | ENSPTRP00000073411 | ENSPTRP00000064444 | annotation not available | Estrogen related receptor beta. | 0.639 |
| ENSPTRP00000073411 | NR0B1 | ENSPTRP00000073411 | ENSPTRP00000047467 | annotation not available | Nuclear receptor subfamily 0 group B member 1; Orphan nuclear receptor. Component of a cascade required for the development of the hypothalamic-pituitary-adrenal-gonadal axis. Acts as a coregulatory protein that inhibits the transcriptional activity of other nuclear receptors through heterodimeric interactions. May also have a role in the development of the embryo and in the maintenance of embryonic stem cell pluripotency (By similarity). Belongs to the nuclear hormone receptor family. NR0 subfamily. | 0.708 |
| ESRRB | ENSPTRP00000071338 | ENSPTRP00000064444 | ENSPTRP00000071338 | Estrogen related receptor beta. | annotation not available | 0.639 |
| ESRRB | ENSPTRP00000073411 | ENSPTRP00000064444 | ENSPTRP00000073411 | Estrogen related receptor beta. | annotation not available | 0.639 |
| ESRRB | ESRRG | ENSPTRP00000064444 | ENSPTRP00000085369 | Estrogen related receptor beta. | Estrogen related receptor gamma. | 0.798 |
| ESRRB | NANOG | ENSPTRP00000064444 | ENSPTRP00000007892 | Estrogen related receptor beta. | Homeobox protein NANOG; Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal. Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes. Acts as a transcriptional activator or repressor. Binds optimally to the DNA consensus sequence 5'-TAAT[GT][GT] [...] | 0.818 |
| ESRRB | NR0B1 | ENSPTRP00000064444 | ENSPTRP00000047467 | Estrogen related receptor beta. | Nuclear receptor subfamily 0 group B member 1; Orphan nuclear receptor. Component of a cascade required for the development of the hypothalamic-pituitary-adrenal-gonadal axis. Acts as a coregulatory protein that inhibits the transcriptional activity of other nuclear receptors through heterodimeric interactions. May also have a role in the development of the embryo and in the maintenance of embryonic stem cell pluripotency (By similarity). Belongs to the nuclear hormone receptor family. NR0 subfamily. | 0.838 |
| ESRRG | ESRRB | ENSPTRP00000085369 | ENSPTRP00000064444 | Estrogen related receptor gamma. | Estrogen related receptor beta. | 0.798 |
| ESRRG | NR0B1 | ENSPTRP00000085369 | ENSPTRP00000047467 | Estrogen related receptor gamma. | Nuclear receptor subfamily 0 group B member 1; Orphan nuclear receptor. Component of a cascade required for the development of the hypothalamic-pituitary-adrenal-gonadal axis. Acts as a coregulatory protein that inhibits the transcriptional activity of other nuclear receptors through heterodimeric interactions. May also have a role in the development of the embryo and in the maintenance of embryonic stem cell pluripotency (By similarity). Belongs to the nuclear hormone receptor family. NR0 subfamily. | 0.863 |
| NANOG | ESRRB | ENSPTRP00000007892 | ENSPTRP00000064444 | Homeobox protein NANOG; Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal. Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes. Acts as a transcriptional activator or repressor. Binds optimally to the DNA consensus sequence 5'-TAAT[GT][GT] [...] | Estrogen related receptor beta. | 0.818 |
| NANOG | NR0B1 | ENSPTRP00000007892 | ENSPTRP00000047467 | Homeobox protein NANOG; Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal. Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes. Acts as a transcriptional activator or repressor. Binds optimally to the DNA consensus sequence 5'-TAAT[GT][GT] [...] | Nuclear receptor subfamily 0 group B member 1; Orphan nuclear receptor. Component of a cascade required for the development of the hypothalamic-pituitary-adrenal-gonadal axis. Acts as a coregulatory protein that inhibits the transcriptional activity of other nuclear receptors through heterodimeric interactions. May also have a role in the development of the embryo and in the maintenance of embryonic stem cell pluripotency (By similarity). Belongs to the nuclear hormone receptor family. NR0 subfamily. | 0.751 |
| NR0B1 | AR | ENSPTRP00000047467 | ENSPTRP00000076864 | Nuclear receptor subfamily 0 group B member 1; Orphan nuclear receptor. Component of a cascade required for the development of the hypothalamic-pituitary-adrenal-gonadal axis. Acts as a coregulatory protein that inhibits the transcriptional activity of other nuclear receptors through heterodimeric interactions. May also have a role in the development of the embryo and in the maintenance of embryonic stem cell pluripotency (By similarity). Belongs to the nuclear hormone receptor family. NR0 subfamily. | Androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3. | 0.786 |
| NR0B1 | ENSPTRP00000071338 | ENSPTRP00000047467 | ENSPTRP00000071338 | Nuclear receptor subfamily 0 group B member 1; Orphan nuclear receptor. Component of a cascade required for the development of the hypothalamic-pituitary-adrenal-gonadal axis. Acts as a coregulatory protein that inhibits the transcriptional activity of other nuclear receptors through heterodimeric interactions. May also have a role in the development of the embryo and in the maintenance of embryonic stem cell pluripotency (By similarity). Belongs to the nuclear hormone receptor family. NR0 subfamily. | annotation not available | 0.708 |
| NR0B1 | ENSPTRP00000073411 | ENSPTRP00000047467 | ENSPTRP00000073411 | Nuclear receptor subfamily 0 group B member 1; Orphan nuclear receptor. Component of a cascade required for the development of the hypothalamic-pituitary-adrenal-gonadal axis. Acts as a coregulatory protein that inhibits the transcriptional activity of other nuclear receptors through heterodimeric interactions. May also have a role in the development of the embryo and in the maintenance of embryonic stem cell pluripotency (By similarity). Belongs to the nuclear hormone receptor family. NR0 subfamily. | annotation not available | 0.708 |
| NR0B1 | ESRRB | ENSPTRP00000047467 | ENSPTRP00000064444 | Nuclear receptor subfamily 0 group B member 1; Orphan nuclear receptor. Component of a cascade required for the development of the hypothalamic-pituitary-adrenal-gonadal axis. Acts as a coregulatory protein that inhibits the transcriptional activity of other nuclear receptors through heterodimeric interactions. May also have a role in the development of the embryo and in the maintenance of embryonic stem cell pluripotency (By similarity). Belongs to the nuclear hormone receptor family. NR0 subfamily. | Estrogen related receptor beta. | 0.838 |
| NR0B1 | ESRRG | ENSPTRP00000047467 | ENSPTRP00000085369 | Nuclear receptor subfamily 0 group B member 1; Orphan nuclear receptor. Component of a cascade required for the development of the hypothalamic-pituitary-adrenal-gonadal axis. Acts as a coregulatory protein that inhibits the transcriptional activity of other nuclear receptors through heterodimeric interactions. May also have a role in the development of the embryo and in the maintenance of embryonic stem cell pluripotency (By similarity). Belongs to the nuclear hormone receptor family. NR0 subfamily. | Estrogen related receptor gamma. | 0.863 |
