TLR8 protein (Pan troglodytes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

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co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CD4	IRAK1-2	ENSPTRP00000054833	ENSPTRP00000038647	T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...]	Interleukin-1 receptor-associated kinase 1.	0.518
CD4	IRAK4	ENSPTRP00000054833	ENSPTRP00000008285	T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...]	Interleukin-1 receptor-associated kinase 4.	0.604
CD4	MYD88	ENSPTRP00000054833	ENSPTRP00000061524	T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...]	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...]	0.877
CD4	TLR3	ENSPTRP00000054833	ENSPTRP00000028569	T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...]	Toll-like receptor 3; Belongs to the Toll-like receptor family.	0.914
CD4	TLR7	ENSPTRP00000054833	ENSPTRP00000047494	T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...]	Toll like receptor 7; Belongs to the Toll-like receptor family.	0.932
CD4	TLR8	ENSPTRP00000054833	ENSPTRP00000062546	T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...]	TLR8 isoform 2; Belongs to the Toll-like receptor family.	0.878
CD4	TLR9	ENSPTRP00000054833	ENSPTRP00000083908	T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...]	T0016681 isoform 1.	0.894
CLEC1B	TLR8	ENSPTRP00000007972	ENSPTRP00000062546	CLEC1B isoform 3.	TLR8 isoform 2; Belongs to the Toll-like receptor family.	0.760
IRAK1-2	CD4	ENSPTRP00000038647	ENSPTRP00000054833	Interleukin-1 receptor-associated kinase 1.	T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...]	0.518
IRAK1-2	IRAK4	ENSPTRP00000038647	ENSPTRP00000008285	Interleukin-1 receptor-associated kinase 1.	Interleukin-1 receptor-associated kinase 4.	0.997
IRAK1-2	MYD88	ENSPTRP00000038647	ENSPTRP00000061524	Interleukin-1 receptor-associated kinase 1.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...]	0.997
IRAK1-2	TLR3	ENSPTRP00000038647	ENSPTRP00000028569	Interleukin-1 receptor-associated kinase 1.	Toll-like receptor 3; Belongs to the Toll-like receptor family.	0.736
IRAK1-2	TLR7	ENSPTRP00000038647	ENSPTRP00000047494	Interleukin-1 receptor-associated kinase 1.	Toll like receptor 7; Belongs to the Toll-like receptor family.	0.972
IRAK1-2	TLR8	ENSPTRP00000038647	ENSPTRP00000062546	Interleukin-1 receptor-associated kinase 1.	TLR8 isoform 2; Belongs to the Toll-like receptor family.	0.961
IRAK1-2	TLR9	ENSPTRP00000038647	ENSPTRP00000083908	Interleukin-1 receptor-associated kinase 1.	T0016681 isoform 1.	0.676
IRAK4	CD4	ENSPTRP00000008285	ENSPTRP00000054833	Interleukin-1 receptor-associated kinase 4.	T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...]	0.604
IRAK4	IRAK1-2	ENSPTRP00000008285	ENSPTRP00000038647	Interleukin-1 receptor-associated kinase 4.	Interleukin-1 receptor-associated kinase 1.	0.997
IRAK4	MYD88	ENSPTRP00000008285	ENSPTRP00000061524	Interleukin-1 receptor-associated kinase 4.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...]	0.999
IRAK4	TLR3	ENSPTRP00000008285	ENSPTRP00000028569	Interleukin-1 receptor-associated kinase 4.	Toll-like receptor 3; Belongs to the Toll-like receptor family.	0.769
IRAK4	TLR7	ENSPTRP00000008285	ENSPTRP00000047494	Interleukin-1 receptor-associated kinase 4.	Toll like receptor 7; Belongs to the Toll-like receptor family.	0.973