| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| FZD5 | LGR4 | ENSPTRP00000021982 | ENSPTRP00000093566 | Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. | LGR4 isoform 2. | 0.921 |
| FZD5 | LGR5 | ENSPTRP00000021982 | ENSPTRP00000080221 | Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. | Leucine rich repeat containing G protein-coupled receptor 5. | 0.550 |
| FZD5 | LRP6 | ENSPTRP00000021982 | ENSPTRP00000008035 | Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. | Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. | 0.997 |
| FZD5 | RNF43 | ENSPTRP00000021982 | ENSPTRP00000056398 | Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. | Ring finger protein 43. | 0.989 |
| FZD5 | ZNRF3 | ENSPTRP00000021982 | ENSPTRP00000024465 | Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. | ZNRF3 isoform 1. | 0.963 |
| LGR4 | FZD5 | ENSPTRP00000093566 | ENSPTRP00000021982 | LGR4 isoform 2. | Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. | 0.921 |
| LGR4 | LGR5 | ENSPTRP00000093566 | ENSPTRP00000080221 | LGR4 isoform 2. | Leucine rich repeat containing G protein-coupled receptor 5. | 0.995 |
| LGR4 | LGR6 | ENSPTRP00000093566 | ENSPTRP00000003094 | LGR4 isoform 2. | LGR6 isoform 2. | 0.925 |
| LGR4 | LRP6 | ENSPTRP00000093566 | ENSPTRP00000008035 | LGR4 isoform 2. | Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. | 0.945 |
| LGR4 | RNF43 | ENSPTRP00000093566 | ENSPTRP00000056398 | LGR4 isoform 2. | Ring finger protein 43. | 0.951 |
| LGR4 | RSPO1 | ENSPTRP00000093566 | ENSPTRP00000000970 | LGR4 isoform 2. | RSPO1 isoform 3. | 0.998 |
| LGR4 | RSPO2 | ENSPTRP00000093566 | ENSPTRP00000063985 | LGR4 isoform 2. | R-spondin 2 homolog. | 0.998 |
| LGR4 | RSPO3 | ENSPTRP00000093566 | ENSPTRP00000031716 | LGR4 isoform 2. | RSPO3 isoform 1. | 0.995 |
| LGR4 | RSPO4 | ENSPTRP00000093566 | ENSPTRP00000022516 | LGR4 isoform 2. | RSPO4 isoform 1. | 0.993 |
| LGR4 | ZNRF3 | ENSPTRP00000093566 | ENSPTRP00000024465 | LGR4 isoform 2. | ZNRF3 isoform 1. | 0.984 |
| LGR5 | FZD5 | ENSPTRP00000080221 | ENSPTRP00000021982 | Leucine rich repeat containing G protein-coupled receptor 5. | Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. | 0.550 |
| LGR5 | LGR4 | ENSPTRP00000080221 | ENSPTRP00000093566 | Leucine rich repeat containing G protein-coupled receptor 5. | LGR4 isoform 2. | 0.995 |
| LGR5 | LGR6 | ENSPTRP00000080221 | ENSPTRP00000003094 | Leucine rich repeat containing G protein-coupled receptor 5. | LGR6 isoform 2. | 0.927 |
| LGR5 | LRP6 | ENSPTRP00000080221 | ENSPTRP00000008035 | Leucine rich repeat containing G protein-coupled receptor 5. | Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. | 0.943 |
| LGR5 | RNF43 | ENSPTRP00000080221 | ENSPTRP00000056398 | Leucine rich repeat containing G protein-coupled receptor 5. | Ring finger protein 43. | 0.937 |
