MAP3K1 protein (Pan troglodytes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc.

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CHUK	IKBKB	ENSPTRP00000084209	ENSPTRP00000034600	Component of inhibitor of nuclear factor kappa B kinase complex.	Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta.	0.999
CHUK	IKBKG	ENSPTRP00000084209	ENSPTRP00000082387	Component of inhibitor of nuclear factor kappa B kinase complex.	Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma.	0.999
CHUK	MAP3K1	ENSPTRP00000084209	ENSPTRP00000048240	Component of inhibitor of nuclear factor kappa B kinase complex.	MAP3K1 isoform 1.	0.981
CHUK	TRAF2	ENSPTRP00000084209	ENSPTRP00000036949	Component of inhibitor of nuclear factor kappa B kinase complex.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.997
CHUK	TRAF6	ENSPTRP00000084209	ENSPTRP00000006096	Component of inhibitor of nuclear factor kappa B kinase complex.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.998
IKBKB	CHUK	ENSPTRP00000034600	ENSPTRP00000084209	Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta.	Component of inhibitor of nuclear factor kappa B kinase complex.	0.999
IKBKB	IKBKG	ENSPTRP00000034600	ENSPTRP00000082387	Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta.	Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma.	0.998
IKBKB	MAP3K1	ENSPTRP00000034600	ENSPTRP00000048240	Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta.	MAP3K1 isoform 1.	0.986
IKBKB	TRAF2	ENSPTRP00000034600	ENSPTRP00000036949	Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.996
IKBKB	TRAF6	ENSPTRP00000034600	ENSPTRP00000006096	Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.998
IKBKG	CHUK	ENSPTRP00000082387	ENSPTRP00000084209	Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma.	Component of inhibitor of nuclear factor kappa B kinase complex.	0.999
IKBKG	IKBKB	ENSPTRP00000082387	ENSPTRP00000034600	Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma.	Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta.	0.998
IKBKG	MAP3K1	ENSPTRP00000082387	ENSPTRP00000048240	Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma.	MAP3K1 isoform 1.	0.978
IKBKG	TRAF2	ENSPTRP00000082387	ENSPTRP00000036949	Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.990
IKBKG	TRAF6	ENSPTRP00000082387	ENSPTRP00000006096	Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.997
MAP2K1	MAP2K4	ENSPTRP00000063228	ENSPTRP00000014968	Dual specificity mitogen-activated protein kinase kinase 1; Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine resid [...]	Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily.	0.426
MAP2K1	MAP3K1	ENSPTRP00000063228	ENSPTRP00000048240	Dual specificity mitogen-activated protein kinase kinase 1; Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine resid [...]	MAP3K1 isoform 1.	0.971
MAP2K1	MAPK10	ENSPTRP00000063228	ENSPTRP00000069952	Dual specificity mitogen-activated protein kinase kinase 1; Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine resid [...]	Mitogen-activated protein kinase.	0.909
MAP2K1	MAPK8	ENSPTRP00000063228	ENSPTRP00000040692	Dual specificity mitogen-activated protein kinase kinase 1; Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine resid [...]	Mitogen-activated protein kinase.	0.919
MAP2K4	MAP2K1	ENSPTRP00000014968	ENSPTRP00000063228	Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily.	Dual specificity mitogen-activated protein kinase kinase 1; Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine resid [...]	0.426