MAP3K1 protein (Pan troglodytes) - STRING interaction network

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gene neighborhood

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Score

MAP3K1

MAP3K1 isoform 1. (1509 aa)

Predicted Functional Partners:

MAP2K4

0.996

TRAF6

0.995

MAPK8

0.990

IKBKB

0.975

CHUK

0.963

MAP2K2

0.961

CDC42

0.961

MAP2K1

0.959

MAPK10

0.959

MAPK9

0.957

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CDC42	MAP2K1	ENSPTRP00000077648	ENSPTRP00000063228	Cell division cycle 42 (GTP binding protein, 25kDa).	Dual specificity mitogen-activated protein kinase kinase 1; Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine resid [...]	0.448
CDC42	MAP3K1	ENSPTRP00000077648	ENSPTRP00000048240	Cell division cycle 42 (GTP binding protein, 25kDa).	MAP3K1 isoform 1.	0.961
CDC42	MAPK10	ENSPTRP00000077648	ENSPTRP00000069952	Cell division cycle 42 (GTP binding protein, 25kDa).	Mitogen-activated protein kinase.	0.946
CDC42	MAPK8	ENSPTRP00000077648	ENSPTRP00000040692	Cell division cycle 42 (GTP binding protein, 25kDa).	Mitogen-activated protein kinase.	0.976
CDC42	MAPK9	ENSPTRP00000077648	ENSPTRP00000030121	Cell division cycle 42 (GTP binding protein, 25kDa).	Mitogen-activated protein kinase.	0.966
CHUK	IKBKB	ENSPTRP00000084209	ENSPTRP00000034600	Component of inhibitor of nuclear factor kappa B kinase complex.	Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta.	0.999
CHUK	MAP3K1	ENSPTRP00000084209	ENSPTRP00000048240	Component of inhibitor of nuclear factor kappa B kinase complex.	MAP3K1 isoform 1.	0.963
CHUK	TRAF6	ENSPTRP00000084209	ENSPTRP00000006096	Component of inhibitor of nuclear factor kappa B kinase complex.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.995
IKBKB	CHUK	ENSPTRP00000034600	ENSPTRP00000084209	Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta.	Component of inhibitor of nuclear factor kappa B kinase complex.	0.999
IKBKB	MAP3K1	ENSPTRP00000034600	ENSPTRP00000048240	Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta.	MAP3K1 isoform 1.	0.975
IKBKB	MAPK8	ENSPTRP00000034600	ENSPTRP00000040692	Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta.	Mitogen-activated protein kinase.	0.504
IKBKB	MAPK9	ENSPTRP00000034600	ENSPTRP00000030121	Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta.	Mitogen-activated protein kinase.	0.434
IKBKB	TRAF6	ENSPTRP00000034600	ENSPTRP00000006096	Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.994
MAP2K1	CDC42	ENSPTRP00000063228	ENSPTRP00000077648	Dual specificity mitogen-activated protein kinase kinase 1; Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine resid [...]	Cell division cycle 42 (GTP binding protein, 25kDa).	0.448
MAP2K1	MAP2K2	ENSPTRP00000063228	ENSPTRP00000017496	Dual specificity mitogen-activated protein kinase kinase 1; Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine resid [...]	Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily.	0.998
MAP2K1	MAP2K4	ENSPTRP00000063228	ENSPTRP00000014968	Dual specificity mitogen-activated protein kinase kinase 1; Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine resid [...]	Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily.	0.601
MAP2K1	MAP3K1	ENSPTRP00000063228	ENSPTRP00000048240	Dual specificity mitogen-activated protein kinase kinase 1; Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine resid [...]	MAP3K1 isoform 1.	0.959
MAP2K1	MAPK10	ENSPTRP00000063228	ENSPTRP00000069952	Dual specificity mitogen-activated protein kinase kinase 1; Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine resid [...]	Mitogen-activated protein kinase.	0.905
MAP2K1	MAPK8	ENSPTRP00000063228	ENSPTRP00000040692	Dual specificity mitogen-activated protein kinase kinase 1; Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine resid [...]	Mitogen-activated protein kinase.	0.922
MAP2K1	MAPK9	ENSPTRP00000063228	ENSPTRP00000030121	Dual specificity mitogen-activated protein kinase kinase 1; Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine resid [...]	Mitogen-activated protein kinase.	0.918