STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CASP10CASP10 isoform 4; Belongs to the peptidase C14A family. (523 aa)    
Predicted Functional Partners:
FADD
FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.
   
 0.999
CASP8
Caspase 8, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family.
    
0.999
CFLAR
CASP8 and FADD-like apoptosis regulator; Belongs to the peptidase C14A family.
   
0.996
TRADD
TNFRSF1A-associated via death domain.
   
 0.990
BID
BH3-interacting domain death agonist; Counters the protective effect of Bcl-2.
   
 0.983
CASP3
Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family.
   
0.976
CASP7
CASP7 isoform 1; Belongs to the peptidase C14A family.
   
0.966
RIPK1
Receptor (TNFRSF)-interacting serine-threonine kinase 1.
   
 0.965
FAS
Fas (TNF receptor superfamily, member 6).
   
 0.956
FASLG
FASLG isoform 1; Belongs to the tumor necrosis factor family.
   
 0.937
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
Server load: medium (52%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.