STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
EPORErythropoietin receptor; Receptor for erythropoietin. (508 aa)    
Predicted Functional Partners:
JAK2
Tyrosine-protein kinase.
    
 0.998
EPO
Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family.
    
 0.991
JAK1
Tyrosine-protein kinase.
    
 0.988
TYK2
Tyrosine-protein kinase.
    
 0.945
GRB2
Growth factor receptor-bound protein 2.
    
 0.934
STAT5A
Signal transducer and activator of transcription.
    
 0.921
EPO-2
Erythropoietin.
    
 0.914
IRS2
IRS2 isoform 1.
    
 0.913
LYN
Tyrosine-protein kinase.
    
 0.908
JAK3
Tyrosine-protein kinase.
    
 0.901
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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