ABCA1 protein (Pan troglodytes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

ABCA1

ATP-binding cassette, sub-family A (ABC1), member 1. (2264 aa)

Predicted Functional Partners:

NR1H2

0.978

APOA1

0.943

RXRA

0.924

NR1H3

0.866

APOE

0.851

LCAT

0.826

SCARB1

0.768

SREBF2

0.764

APOA2

0.760

SREBF1

0.737

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABCA1	APOA1	ENSPTRP00000062700	ENSPTRP00000007404	ATP-binding cassette, sub-family A (ABC1), member 1.	Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility (By similarity).	0.943
ABCA1	APOA2	ENSPTRP00000062700	ENSPTRP00000069102	ATP-binding cassette, sub-family A (ABC1), member 1.	Truncated apolipoprotein A-II; May stabilize HDL (high density lipoprotein) structure by its association with lipids, and affect the HDL metabolism; Belongs to the apolipoprotein A2 family.	0.760
ABCA1	APOE	ENSPTRP00000062700	ENSPTRP00000054411	ATP-binding cassette, sub-family A (ABC1), member 1.	Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...]	0.851
ABCA1	LCAT	ENSPTRP00000062700	ENSPTRP00000014085	ATP-binding cassette, sub-family A (ABC1), member 1.	Lecithin-cholesterol acyltransferase.	0.826
ABCA1	NR1H2	ENSPTRP00000062700	ENSPTRP00000019472	ATP-binding cassette, sub-family A (ABC1), member 1.	Nuclear receptor subfamily 1, group H, member 2.	0.978
ABCA1	NR1H3	ENSPTRP00000062700	ENSPTRP00000079039	ATP-binding cassette, sub-family A (ABC1), member 1.	Nuclear receptor subfamily 1 group H member 3.	0.866
ABCA1	RXRA	ENSPTRP00000062700	ENSPTRP00000045122	ATP-binding cassette, sub-family A (ABC1), member 1.	Retinoid X receptor, alpha.	0.924
ABCA1	SCARB1	ENSPTRP00000062700	ENSPTRP00000079498	ATP-binding cassette, sub-family A (ABC1), member 1.	SCARB1 isoform 8; Belongs to the CD36 family.	0.768
ABCA1	SREBF1	ENSPTRP00000062700	ENSPTRP00000076133	ATP-binding cassette, sub-family A (ABC1), member 1.	SREBF1 isoform 6.	0.737
ABCA1	SREBF2	ENSPTRP00000062700	ENSPTRP00000024869	ATP-binding cassette, sub-family A (ABC1), member 1.	Sterol regulatory element binding transcription factor 2.	0.764
APOA1	ABCA1	ENSPTRP00000007404	ENSPTRP00000062700	Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility (By similarity).	ATP-binding cassette, sub-family A (ABC1), member 1.	0.943
APOA1	APOA2	ENSPTRP00000007404	ENSPTRP00000069102	Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility (By similarity).	Truncated apolipoprotein A-II; May stabilize HDL (high density lipoprotein) structure by its association with lipids, and affect the HDL metabolism; Belongs to the apolipoprotein A2 family.	0.800
APOA1	APOE	ENSPTRP00000007404	ENSPTRP00000054411	Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility (By similarity).	Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...]	0.862
APOA1	LCAT	ENSPTRP00000007404	ENSPTRP00000014085	Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility (By similarity).	Lecithin-cholesterol acyltransferase.	0.970
APOA2	ABCA1	ENSPTRP00000069102	ENSPTRP00000062700	Truncated apolipoprotein A-II; May stabilize HDL (high density lipoprotein) structure by its association with lipids, and affect the HDL metabolism; Belongs to the apolipoprotein A2 family.	ATP-binding cassette, sub-family A (ABC1), member 1.	0.760
APOA2	APOA1	ENSPTRP00000069102	ENSPTRP00000007404	Truncated apolipoprotein A-II; May stabilize HDL (high density lipoprotein) structure by its association with lipids, and affect the HDL metabolism; Belongs to the apolipoprotein A2 family.	Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility (By similarity).	0.800
APOA2	APOE	ENSPTRP00000069102	ENSPTRP00000054411	Truncated apolipoprotein A-II; May stabilize HDL (high density lipoprotein) structure by its association with lipids, and affect the HDL metabolism; Belongs to the apolipoprotein A2 family.	Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...]	0.995
APOA2	LCAT	ENSPTRP00000069102	ENSPTRP00000014085	Truncated apolipoprotein A-II; May stabilize HDL (high density lipoprotein) structure by its association with lipids, and affect the HDL metabolism; Belongs to the apolipoprotein A2 family.	Lecithin-cholesterol acyltransferase.	0.888
APOA2	SCARB1	ENSPTRP00000069102	ENSPTRP00000079498	Truncated apolipoprotein A-II; May stabilize HDL (high density lipoprotein) structure by its association with lipids, and affect the HDL metabolism; Belongs to the apolipoprotein A2 family.	SCARB1 isoform 8; Belongs to the CD36 family.	0.671
APOE	ABCA1	ENSPTRP00000054411	ENSPTRP00000062700	Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...]	ATP-binding cassette, sub-family A (ABC1), member 1.	0.851