| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CFL1 | CFL2 | ENSPTRP00000087369 | ENSPTRP00000010616 | CFL1 isoform 2; Belongs to the actin-binding proteins ADF family. | Cofilin 2 (Muscle); Belongs to the actin-binding proteins ADF family. | 0.998 |
| CFL1 | LIMK1-2 | ENSPTRP00000087369 | ENSPTRP00000079435 | CFL1 isoform 2; Belongs to the actin-binding proteins ADF family. | LIM domain kinase 1. | 0.995 |
| CFL1 | LIMK2 | ENSPTRP00000087369 | ENSPTRP00000049722 | CFL1 isoform 2; Belongs to the actin-binding proteins ADF family. | LIMK2 isoform 6. | 0.989 |
| CFL1 | ROCK1 | ENSPTRP00000087369 | ENSPTRP00000084841 | CFL1 isoform 2; Belongs to the actin-binding proteins ADF family. | Rho-associated protein kinase 1; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, TPPP, PFN1 and PPP1R12A. Phosphorylates FHOD1 and acts synergistically with it to promote SRC-dependent non-apoptotic plasma membrane blebbing. Phosphorylates JIP3 and regulates the recruitment of JNK to JIP3 upon UVB-induced stress (By simi [...] | 0.686 |
| CFL1 | ROCK2 | ENSPTRP00000087369 | ENSPTRP00000063417 | CFL1 isoform 2; Belongs to the actin-binding proteins ADF family. | Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. | 0.640 |
| CFL2 | CFL1 | ENSPTRP00000010616 | ENSPTRP00000087369 | Cofilin 2 (Muscle); Belongs to the actin-binding proteins ADF family. | CFL1 isoform 2; Belongs to the actin-binding proteins ADF family. | 0.998 |
| CFL2 | LIMK1-2 | ENSPTRP00000010616 | ENSPTRP00000079435 | Cofilin 2 (Muscle); Belongs to the actin-binding proteins ADF family. | LIM domain kinase 1. | 0.982 |
| CFL2 | LIMK2 | ENSPTRP00000010616 | ENSPTRP00000049722 | Cofilin 2 (Muscle); Belongs to the actin-binding proteins ADF family. | LIMK2 isoform 6. | 0.975 |
| CFL2 | PAK1 | ENSPTRP00000010616 | ENSPTRP00000007058 | Cofilin 2 (Muscle); Belongs to the actin-binding proteins ADF family. | Non-specific serine/threonine protein kinase. | 0.406 |
| CFL2 | ROCK1 | ENSPTRP00000010616 | ENSPTRP00000084841 | Cofilin 2 (Muscle); Belongs to the actin-binding proteins ADF family. | Rho-associated protein kinase 1; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, TPPP, PFN1 and PPP1R12A. Phosphorylates FHOD1 and acts synergistically with it to promote SRC-dependent non-apoptotic plasma membrane blebbing. Phosphorylates JIP3 and regulates the recruitment of JNK to JIP3 upon UVB-induced stress (By simi [...] | 0.611 |
| CFL2 | ROCK2 | ENSPTRP00000010616 | ENSPTRP00000063417 | Cofilin 2 (Muscle); Belongs to the actin-binding proteins ADF family. | Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. | 0.535 |
| LIMK1-2 | CFL1 | ENSPTRP00000079435 | ENSPTRP00000087369 | LIM domain kinase 1. | CFL1 isoform 2; Belongs to the actin-binding proteins ADF family. | 0.995 |
| LIMK1-2 | CFL2 | ENSPTRP00000079435 | ENSPTRP00000010616 | LIM domain kinase 1. | Cofilin 2 (Muscle); Belongs to the actin-binding proteins ADF family. | 0.982 |
| LIMK1-2 | LIMK2 | ENSPTRP00000079435 | ENSPTRP00000049722 | LIM domain kinase 1. | LIMK2 isoform 6. | 0.985 |
| LIMK1-2 | PAK1 | ENSPTRP00000079435 | ENSPTRP00000007058 | LIM domain kinase 1. | Non-specific serine/threonine protein kinase. | 0.971 |
| LIMK1-2 | PAK3 | ENSPTRP00000079435 | ENSPTRP00000062580 | LIM domain kinase 1. | Serine/threonine-protein kinase PAK 3; Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, or cell cycle regulation. Plays a role in dendrite spine morphogenesis as well as synapse formation and plasticity. Acts as downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates MAPK4 and MAPK6 and activates the downstrea [...] | 0.959 |
| LIMK1-2 | PAK4 | ENSPTRP00000079435 | ENSPTRP00000090146 | LIM domain kinase 1. | Non-specific serine/threonine protein kinase. | 0.941 |
| LIMK1-2 | PAK5 | ENSPTRP00000079435 | ENSPTRP00000022716 | LIM domain kinase 1. | Non-specific serine/threonine protein kinase. | 0.938 |
| LIMK1-2 | PAK6 | ENSPTRP00000079435 | ENSPTRP00000011806 | LIM domain kinase 1. | Non-specific serine/threonine protein kinase. | 0.937 |
| LIMK1-2 | ROCK1 | ENSPTRP00000079435 | ENSPTRP00000084841 | LIM domain kinase 1. | Rho-associated protein kinase 1; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, TPPP, PFN1 and PPP1R12A. Phosphorylates FHOD1 and acts synergistically with it to promote SRC-dependent non-apoptotic plasma membrane blebbing. Phosphorylates JIP3 and regulates the recruitment of JNK to JIP3 upon UVB-induced stress (By simi [...] | 0.949 |
