| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| GPR132 | P2RX7 | ENSPTRP00000063923 | ENSPTRP00000049853 | G protein-coupled receptor 132; Belongs to the G-protein coupled receptor 1 family. | P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. | 0.442 |
| IL18 | IL1B | ENSPTRP00000007359 | ENSPTRP00000021191 | Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. | Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. | 0.939 |
| IL18 | P2RX7 | ENSPTRP00000007359 | ENSPTRP00000049853 | Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. | P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. | 0.439 |
| IL1B | IL18 | ENSPTRP00000021191 | ENSPTRP00000007359 | Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. | Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. | 0.939 |
| IL1B | P2RX7 | ENSPTRP00000021191 | ENSPTRP00000049853 | Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. | P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. | 0.495 |
| IL1B | PANX1 | ENSPTRP00000021191 | ENSPTRP00000007193 | Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. | Pannexin; Structural component of the gap junctions and the hemichannels. | 0.404 |
| P2RX5 | P2RX7 | ENSPTRP00000053185 | ENSPTRP00000049853 | P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. | P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. | 0.582 |
| P2RX5 | P2RY2 | ENSPTRP00000053185 | ENSPTRP00000006950 | P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. | Purinergic receptor P2Y2; Belongs to the G-protein coupled receptor 1 family. | 0.495 |
| P2RX5 | P2RY4 | ENSPTRP00000053185 | ENSPTRP00000057506 | P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. | Pyrimidinergic receptor P2Y4; Belongs to the G-protein coupled receptor 1 family. | 0.495 |
| P2RX5 | P2RY6 | ENSPTRP00000053185 | ENSPTRP00000006953 | P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. | Pyrimidinergic receptor P2Y6. | 0.495 |
| P2RX7 | GPR132 | ENSPTRP00000049853 | ENSPTRP00000063923 | P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. | G protein-coupled receptor 132; Belongs to the G-protein coupled receptor 1 family. | 0.442 |
| P2RX7 | IL18 | ENSPTRP00000049853 | ENSPTRP00000007359 | P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. | Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. | 0.439 |
| P2RX7 | IL1B | ENSPTRP00000049853 | ENSPTRP00000021191 | P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. | Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. | 0.495 |
| P2RX7 | P2RX5 | ENSPTRP00000049853 | ENSPTRP00000053185 | P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. | P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. | 0.582 |
| P2RX7 | P2RY1 | ENSPTRP00000049853 | ENSPTRP00000026760 | P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. | Purinergic receptor P2Y1; Belongs to the G-protein coupled receptor 1 family. | 0.424 |
| P2RX7 | P2RY2 | ENSPTRP00000049853 | ENSPTRP00000006950 | P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. | Purinergic receptor P2Y2; Belongs to the G-protein coupled receptor 1 family. | 0.557 |
| P2RX7 | P2RY4 | ENSPTRP00000049853 | ENSPTRP00000057506 | P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. | Pyrimidinergic receptor P2Y4; Belongs to the G-protein coupled receptor 1 family. | 0.495 |
| P2RX7 | P2RY6 | ENSPTRP00000049853 | ENSPTRP00000006953 | P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. | Pyrimidinergic receptor P2Y6. | 0.495 |
| P2RX7 | PANX1 | ENSPTRP00000049853 | ENSPTRP00000007193 | P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. | Pannexin; Structural component of the gap junctions and the hemichannels. | 0.919 |
| P2RX7 | PPAN | ENSPTRP00000049853 | ENSPTRP00000041462 | P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. | PPAN-P2RY11 isoform 1. | 0.424 |
