STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
LTBLymphotoxin-beta; Cytokine that binds to LTBR/TNFRSF3. May play a specific role in immune response regulation. Provides the membrane anchor for the attachment of the heterotrimeric complex to the cell surface (By similarity). (244 aa)    
Predicted Functional Partners:
LTBR
Lymphotoxin beta receptor (TNFR superfamily, member 3).
   
 0.999
LTA
Lymphotoxin-alpha; Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM (By similarity). In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and is cytotoxic for a wide range of tumor cells in vitro and in vivo (By similarity).
   
0.999
TNFRSF14
Tumor necrosis factor receptor superfamily, member 14 (Herpesvirus entry mediator).
   
 0.765
SNX2
Sorting nexin 2.
      
 0.744
LST1
Leukocyte specific transcript 1.
  
  
 0.737
TNFRSF1B
Tumor necrosis factor receptor superfamily, member 1B.
   
 
 0.705
RELB
RELB isoform 3.
   
  
 0.697
TNFSF13B
Tumor necrosis factor ligand 7A; Belongs to the tumor necrosis factor family.
   
 
 0.694
CD40LG
CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.
   
 
 0.683
TNFRSF13C
TNF receptor superfamily member 13C.
   
 
 0.676
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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