| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CTH | MAT1A | ENSPTRP00000001478 | ENSPTRP00000004677 | Cystathionase (Cystathionine gamma-lyase). | S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP. | 0.482 |
| CTH | MAT2A | ENSPTRP00000001478 | ENSPTRP00000020815 | Cystathionase (Cystathionine gamma-lyase). | S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP. | 0.482 |
| CTH | MTHFR | ENSPTRP00000001478 | ENSPTRP00000000294 | Cystathionase (Cystathionine gamma-lyase). | Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.948 |
| CTH | MTR | ENSPTRP00000001478 | ENSPTRP00000051007 | Cystathionase (Cystathionine gamma-lyase). | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.987 |
| CTH | MTRR | ENSPTRP00000001478 | ENSPTRP00000028690 | Cystathionase (Cystathionine gamma-lyase). | MTRR isoform 2. | 0.699 |
| DMGDH | MTHFD1 | ENSPTRP00000029147 | ENSPTRP00000010916 | Dimethylglycine dehydrogenase. | MTHFD1 isoform 1. | 0.947 |
| DMGDH | MTHFD1L | ENSPTRP00000029147 | ENSPTRP00000031922 | Dimethylglycine dehydrogenase. | Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like. | 0.952 |
| DMGDH | MTHFR | ENSPTRP00000029147 | ENSPTRP00000000294 | Dimethylglycine dehydrogenase. | Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.984 |
| DMGDH | MTR | ENSPTRP00000029147 | ENSPTRP00000051007 | Dimethylglycine dehydrogenase. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.977 |
| DMGDH | SHMT1 | ENSPTRP00000029147 | ENSPTRP00000076664 | Dimethylglycine dehydrogenase. | Serine hydroxymethyltransferase 1. | 0.979 |
| DMGDH | SHMT2 | ENSPTRP00000029147 | ENSPTRP00000063004 | Dimethylglycine dehydrogenase. | Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. | 0.988 |
| MAT1A | CTH | ENSPTRP00000004677 | ENSPTRP00000001478 | S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP. | Cystathionase (Cystathionine gamma-lyase). | 0.482 |
| MAT1A | MAT2A | ENSPTRP00000004677 | ENSPTRP00000020815 | S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP. | S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP. | 0.990 |
| MAT1A | MTHFR | ENSPTRP00000004677 | ENSPTRP00000000294 | S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP. | Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.866 |
| MAT1A | MTR | ENSPTRP00000004677 | ENSPTRP00000051007 | S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.972 |
| MAT1A | SHMT1 | ENSPTRP00000004677 | ENSPTRP00000076664 | S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP. | Serine hydroxymethyltransferase 1. | 0.620 |
| MAT1A | SHMT2 | ENSPTRP00000004677 | ENSPTRP00000063004 | S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP. | Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. | 0.620 |
| MAT2A | CTH | ENSPTRP00000020815 | ENSPTRP00000001478 | S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP. | Cystathionase (Cystathionine gamma-lyase). | 0.482 |
| MAT2A | MAT1A | ENSPTRP00000020815 | ENSPTRP00000004677 | S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP. | S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP. | 0.990 |
| MAT2A | MTHFR | ENSPTRP00000020815 | ENSPTRP00000000294 | S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP. | Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.866 |
