GUK1 protein (Pan troglodytes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

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textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADSL	AK9	ENSPTRP00000093087	ENSPTRP00000031578	Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.	Adenylate kinase 9.	0.993
ADSL	GMPR	ENSPTRP00000093087	ENSPTRP00000030306	Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.	GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.	0.653
ADSL	GUK1	ENSPTRP00000093087	ENSPTRP00000076597	Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.	Guanylate kinase 1.	0.936
ADSL	HPRT1	ENSPTRP00000093087	ENSPTRP00000086770	Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.	Hypoxanthine-guanine phosphoribosyltransferase; Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5-phosphoribosyl group from 5- phosphoribosylpyrophosphate onto the purine. Plays a central role in the generation of purine nucleotides through the purine salvage pathway (By similarity).	0.677
ADSL	RRM1	ENSPTRP00000093087	ENSPTRP00000005668	Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.	Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.	0.444
AK9	ADSL	ENSPTRP00000031578	ENSPTRP00000093087	Adenylate kinase 9.	Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.	0.993
AK9	GUK1	ENSPTRP00000031578	ENSPTRP00000076597	Adenylate kinase 9.	Guanylate kinase 1.	0.947
AK9	NME1	ENSPTRP00000031578	ENSPTRP00000015996	Adenylate kinase 9.	NME1 isoform 6; Belongs to the NDK family.	0.959
AK9	NME6	ENSPTRP00000031578	ENSPTRP00000025673	Adenylate kinase 9.	Nucleoside diphosphate kinase.	0.959
AK9	NME7	ENSPTRP00000031578	ENSPTRP00000002753	Adenylate kinase 9.	Nucleoside diphosphate kinase 7; Belongs to the NDK family.	0.959
AK9	RRM1	ENSPTRP00000031578	ENSPTRP00000005668	Adenylate kinase 9.	Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.	0.994
AK9	RRM2	ENSPTRP00000031578	ENSPTRP00000063965	Adenylate kinase 9.	Ribonucleotide reductase regulatory subunit M2.	0.983
AK9	RRM2B	ENSPTRP00000031578	ENSPTRP00000081496	Adenylate kinase 9.	Ribonucleotide reductase regulatory TP53 inducible subunit M2B.	0.983
GMPR	ADSL	ENSPTRP00000030306	ENSPTRP00000093087	GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.	Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.	0.653
GMPR	GUK1	ENSPTRP00000030306	ENSPTRP00000076597	GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.	Guanylate kinase 1.	0.933
GMPR	HPRT1	ENSPTRP00000030306	ENSPTRP00000086770	GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.	Hypoxanthine-guanine phosphoribosyltransferase; Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5-phosphoribosyl group from 5- phosphoribosylpyrophosphate onto the purine. Plays a central role in the generation of purine nucleotides through the purine salvage pathway (By similarity).	0.920
GUK1	ADSL	ENSPTRP00000076597	ENSPTRP00000093087	Guanylate kinase 1.	Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.	0.936
GUK1	AK9	ENSPTRP00000076597	ENSPTRP00000031578	Guanylate kinase 1.	Adenylate kinase 9.	0.947
GUK1	GMPR	ENSPTRP00000076597	ENSPTRP00000030306	Guanylate kinase 1.	GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.	0.933
GUK1	HPRT1	ENSPTRP00000076597	ENSPTRP00000086770	Guanylate kinase 1.	Hypoxanthine-guanine phosphoribosyltransferase; Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5-phosphoribosyl group from 5- phosphoribosylpyrophosphate onto the purine. Plays a central role in the generation of purine nucleotides through the purine salvage pathway (By similarity).	0.935