STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TM2D3TM2 domain containing 3. (247 aa)    
Predicted Functional Partners:
ZC3H12A
Zinc finger CCCH-type containing 12A.
      
 0.766
UCP3
Uncoupling protein 3; Belongs to the mitochondrial carrier (TC 2.A.29) family.
      
 0.764
NUFIP2
Nuclear fragile X mental retardation protein interacting protein 2.
      
 0.637
MAP3K5
Mitogen-activated protein kinase kinase kinase 5.
      
 0.633
NME8
NME/NM23 family member 8.
      
 0.545
CCN1
CCN family member 1; Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up- regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5 (By similarity). CCN1-mediated gene regulation is dependent on heparin-binding (By similarity). Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1 (By similarity). Promotes cell adhesion and adhesive s [...]
      
 0.511
TFRC
Transferrin receptor (P90, CD71).
      
 0.510
LRCH1
Leucine rich repeats and calponin homology domain containing 1.
      
 0.493
TARS3
Threonyl-tRNA synthetase-like 2.
 
    
 0.484
OR4F15
Olfactory receptor.
      
 0.465
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.