| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ACE | ACE2 | ENSPTRP00000038991 | ENSPTRP00000037158 | Angiotensin-converting enzyme, soluble form; Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI- anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety (By similarity); Belongs to the peptidase M2 family. | Angiotensin-converting enzyme. | 0.957 |
| ACE | AGT | ENSPTRP00000038991 | ENSPTRP00000003543 | Angiotensin-converting enzyme, soluble form; Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI- anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety (By similarity); Belongs to the peptidase M2 family. | Angiotensin 1-4; Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis. [Angiotensin-3]: stimulates aldosterone release. | 0.997 |
| ACE | ATP6AP2 | ENSPTRP00000038991 | ENSPTRP00000037408 | Angiotensin-converting enzyme, soluble form; Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI- anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety (By similarity); Belongs to the peptidase M2 family. | ATPase, H+ transporting, lysosomal accessory protein 2. | 0.525 |
| ACE | CMA1 | ENSPTRP00000038991 | ENSPTRP00000010563 | Angiotensin-converting enzyme, soluble form; Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI- anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety (By similarity); Belongs to the peptidase M2 family. | CMA1 isoform 1; Belongs to the peptidase S1 family. | 0.589 |
| ACE | CTSA | ENSPTRP00000038991 | ENSPTRP00000074794 | Angiotensin-converting enzyme, soluble form; Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI- anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety (By similarity); Belongs to the peptidase M2 family. | Carboxypeptidase; Belongs to the peptidase S10 family. | 0.907 |
| ACE | MME | ENSPTRP00000038991 | ENSPTRP00000090405 | Angiotensin-converting enzyme, soluble form; Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI- anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety (By similarity); Belongs to the peptidase M2 family. | Membrane metallo-endopeptidase. | 0.969 |
| ACE | NLN | ENSPTRP00000038991 | ENSPTRP00000028990 | Angiotensin-converting enzyme, soluble form; Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI- anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety (By similarity); Belongs to the peptidase M2 family. | Neurolysin (Metallopeptidase M3 family). | 0.947 |
| ACE | REN | ENSPTRP00000038991 | ENSPTRP00000051292 | Angiotensin-converting enzyme, soluble form; Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI- anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety (By similarity); Belongs to the peptidase M2 family. | Renin; Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney. | 0.991 |
| ACE2 | ACE | ENSPTRP00000037158 | ENSPTRP00000038991 | Angiotensin-converting enzyme. | Angiotensin-converting enzyme, soluble form; Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI- anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety (By similarity); Belongs to the peptidase M2 family. | 0.957 |
| ACE2 | AGT | ENSPTRP00000037158 | ENSPTRP00000003543 | Angiotensin-converting enzyme. | Angiotensin 1-4; Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis. [Angiotensin-3]: stimulates aldosterone release. | 0.994 |
| ACE2 | ATP6AP2 | ENSPTRP00000037158 | ENSPTRP00000037408 | Angiotensin-converting enzyme. | ATPase, H+ transporting, lysosomal accessory protein 2. | 0.462 |
| ACE2 | CMA1 | ENSPTRP00000037158 | ENSPTRP00000010563 | Angiotensin-converting enzyme. | CMA1 isoform 1; Belongs to the peptidase S1 family. | 0.950 |
| ACE2 | CTSG | ENSPTRP00000037158 | ENSPTRP00000010565 | Angiotensin-converting enzyme. | CTSG isoform 2; Belongs to the peptidase S1 family. | 0.928 |
| ACE2 | MME | ENSPTRP00000037158 | ENSPTRP00000090405 | Angiotensin-converting enzyme. | Membrane metallo-endopeptidase. | 0.959 |
| ACE2 | REN | ENSPTRP00000037158 | ENSPTRP00000051292 | Angiotensin-converting enzyme. | Renin; Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney. | 0.989 |
| AGT | ACE | ENSPTRP00000003543 | ENSPTRP00000038991 | Angiotensin 1-4; Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis. [Angiotensin-3]: stimulates aldosterone release. | Angiotensin-converting enzyme, soluble form; Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI- anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety (By similarity); Belongs to the peptidase M2 family. | 0.997 |
| AGT | ACE2 | ENSPTRP00000003543 | ENSPTRP00000037158 | Angiotensin 1-4; Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis. [Angiotensin-3]: stimulates aldosterone release. | Angiotensin-converting enzyme. | 0.994 |
| AGT | ATP6AP2 | ENSPTRP00000003543 | ENSPTRP00000037408 | Angiotensin 1-4; Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis. [Angiotensin-3]: stimulates aldosterone release. | ATPase, H+ transporting, lysosomal accessory protein 2. | 0.941 |
| AGT | CMA1 | ENSPTRP00000003543 | ENSPTRP00000010563 | Angiotensin 1-4; Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis. [Angiotensin-3]: stimulates aldosterone release. | CMA1 isoform 1; Belongs to the peptidase S1 family. | 0.940 |
| AGT | CTSG | ENSPTRP00000003543 | ENSPTRP00000010565 | Angiotensin 1-4; Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis. [Angiotensin-3]: stimulates aldosterone release. | CTSG isoform 2; Belongs to the peptidase S1 family. | 0.817 |
