HRH1 protein (Pan troglodytes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

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node degree of proteins in your network (given the current score cut-off)

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a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
GNA11	GNA14	ENSPTRP00000074292	ENSPTRP00000091799	Guanine nucleotide binding protein (G protein), alpha 11 (Gq class).	Guanine nucleotide binding protein (G protein), alpha 14.	0.949
GNA11	GNA15	ENSPTRP00000074292	ENSPTRP00000093570	Guanine nucleotide binding protein (G protein), alpha 11 (Gq class).	G protein subunit alpha 15.	0.510
GNA11	GNAI2	ENSPTRP00000074292	ENSPTRP00000025802	Guanine nucleotide binding protein (G protein), alpha 11 (Gq class).	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2.	0.552
GNA11	GNAQ	ENSPTRP00000074292	ENSPTRP00000049267	Guanine nucleotide binding protein (G protein), alpha 11 (Gq class).	Guanine nucleotide binding protein (G protein), q polypeptide.	0.997
GNA11	GNB1	ENSPTRP00000074292	ENSPTRP00000067330	Guanine nucleotide binding protein (G protein), alpha 11 (Gq class).	Guanine nucleotide binding protein (G protein), beta polypeptide 1.	0.922
GNA11	GNG2	ENSPTRP00000074292	ENSPTRP00000065345	Guanine nucleotide binding protein (G protein), alpha 11 (Gq class).	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.804
GNA11	HRH1	ENSPTRP00000074292	ENSPTRP00000051571	Guanine nucleotide binding protein (G protein), alpha 11 (Gq class).	Histamine H1 receptor; In peripheral tissues, the H1 subclass of histamine receptors mediates the contraction of smooth muscles, increase in capillary permeability due to contraction of terminal venules, and catecholamine release from adrenal medulla, as well as mediating neurotransmission in the central nervous system.	0.936
GNA11	PLCB3	ENSPTRP00000074292	ENSPTRP00000085540	Guanine nucleotide binding protein (G protein), alpha 11 (Gq class).	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.	0.963
GNA14	GNA11	ENSPTRP00000091799	ENSPTRP00000074292	Guanine nucleotide binding protein (G protein), alpha 14.	Guanine nucleotide binding protein (G protein), alpha 11 (Gq class).	0.949
GNA14	GNA15	ENSPTRP00000091799	ENSPTRP00000093570	Guanine nucleotide binding protein (G protein), alpha 14.	G protein subunit alpha 15.	0.925
GNA14	GNAI2	ENSPTRP00000091799	ENSPTRP00000025802	Guanine nucleotide binding protein (G protein), alpha 14.	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2.	0.926
GNA14	GNAQ	ENSPTRP00000091799	ENSPTRP00000049267	Guanine nucleotide binding protein (G protein), alpha 14.	Guanine nucleotide binding protein (G protein), q polypeptide.	0.991
GNA14	GNB1	ENSPTRP00000091799	ENSPTRP00000067330	Guanine nucleotide binding protein (G protein), alpha 14.	Guanine nucleotide binding protein (G protein), beta polypeptide 1.	0.972
GNA14	GNG2	ENSPTRP00000091799	ENSPTRP00000065345	Guanine nucleotide binding protein (G protein), alpha 14.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.960
GNA14	HRH1	ENSPTRP00000091799	ENSPTRP00000051571	Guanine nucleotide binding protein (G protein), alpha 14.	Histamine H1 receptor; In peripheral tissues, the H1 subclass of histamine receptors mediates the contraction of smooth muscles, increase in capillary permeability due to contraction of terminal venules, and catecholamine release from adrenal medulla, as well as mediating neurotransmission in the central nervous system.	0.790
GNA14	PLCB3	ENSPTRP00000091799	ENSPTRP00000085540	Guanine nucleotide binding protein (G protein), alpha 14.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.	0.963
GNA15	GNA11	ENSPTRP00000093570	ENSPTRP00000074292	G protein subunit alpha 15.	Guanine nucleotide binding protein (G protein), alpha 11 (Gq class).	0.510
GNA15	GNA14	ENSPTRP00000093570	ENSPTRP00000091799	G protein subunit alpha 15.	Guanine nucleotide binding protein (G protein), alpha 14.	0.925
GNA15	GNAI2	ENSPTRP00000093570	ENSPTRP00000025802	G protein subunit alpha 15.	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2.	0.911
GNA15	GNAQ	ENSPTRP00000093570	ENSPTRP00000049267	G protein subunit alpha 15.	Guanine nucleotide binding protein (G protein), q polypeptide.	0.919