| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| MC2R | MC4R | ENSPTRP00000084771 | ENSPTRP00000017101 | Melanocortin 2 receptor. | Melanocortin 4 receptor. | 0.916 |
| MC2R | MRAP | ENSPTRP00000084771 | ENSPTRP00000055057 | Melanocortin 2 receptor. | Melanocortin-2 receptor accessory protein; Modulator of melanocortin receptors (MC1R, MC2R, MC3R, MC4R and MC5R). Acts by increasing ligand-sensitivity of melanocortin receptors and enhancing generation of cAMP by the receptors. Required both for MC2R trafficking to the cell surface of adrenal cells and for signaling in response to corticotropin (ACTH). May be involved in the intracellular trafficking pathways in adipocyte cells (By similarity). Belongs to the MRAP family. | 0.994 |
| MC2R | POMC | ENSPTRP00000084771 | ENSPTRP00000052139 | Melanocortin 2 receptor. | Proopiomelanocortin. | 0.999 |
| MC4R | MC2R | ENSPTRP00000017101 | ENSPTRP00000084771 | Melanocortin 4 receptor. | Melanocortin 2 receptor. | 0.916 |
| MC4R | MRAP | ENSPTRP00000017101 | ENSPTRP00000055057 | Melanocortin 4 receptor. | Melanocortin-2 receptor accessory protein; Modulator of melanocortin receptors (MC1R, MC2R, MC3R, MC4R and MC5R). Acts by increasing ligand-sensitivity of melanocortin receptors and enhancing generation of cAMP by the receptors. Required both for MC2R trafficking to the cell surface of adrenal cells and for signaling in response to corticotropin (ACTH). May be involved in the intracellular trafficking pathways in adipocyte cells (By similarity). Belongs to the MRAP family. | 0.669 |
| MC4R | PDYN | ENSPTRP00000017101 | ENSPTRP00000022551 | Melanocortin 4 receptor. | PDYN isoform 1. | 0.479 |
| MC4R | PENK | ENSPTRP00000017101 | ENSPTRP00000034706 | Melanocortin 4 receptor. | PENK isoform 3. | 0.403 |
| MC4R | POMC | ENSPTRP00000017101 | ENSPTRP00000052139 | Melanocortin 4 receptor. | Proopiomelanocortin. | 0.998 |
| MRAP | MC2R | ENSPTRP00000055057 | ENSPTRP00000084771 | Melanocortin-2 receptor accessory protein; Modulator of melanocortin receptors (MC1R, MC2R, MC3R, MC4R and MC5R). Acts by increasing ligand-sensitivity of melanocortin receptors and enhancing generation of cAMP by the receptors. Required both for MC2R trafficking to the cell surface of adrenal cells and for signaling in response to corticotropin (ACTH). May be involved in the intracellular trafficking pathways in adipocyte cells (By similarity). Belongs to the MRAP family. | Melanocortin 2 receptor. | 0.994 |
| MRAP | MC4R | ENSPTRP00000055057 | ENSPTRP00000017101 | Melanocortin-2 receptor accessory protein; Modulator of melanocortin receptors (MC1R, MC2R, MC3R, MC4R and MC5R). Acts by increasing ligand-sensitivity of melanocortin receptors and enhancing generation of cAMP by the receptors. Required both for MC2R trafficking to the cell surface of adrenal cells and for signaling in response to corticotropin (ACTH). May be involved in the intracellular trafficking pathways in adipocyte cells (By similarity). Belongs to the MRAP family. | Melanocortin 4 receptor. | 0.669 |
| MRAP | POMC | ENSPTRP00000055057 | ENSPTRP00000052139 | Melanocortin-2 receptor accessory protein; Modulator of melanocortin receptors (MC1R, MC2R, MC3R, MC4R and MC5R). Acts by increasing ligand-sensitivity of melanocortin receptors and enhancing generation of cAMP by the receptors. Required both for MC2R trafficking to the cell surface of adrenal cells and for signaling in response to corticotropin (ACTH). May be involved in the intracellular trafficking pathways in adipocyte cells (By similarity). Belongs to the MRAP family. | Proopiomelanocortin. | 0.985 |
| OPRD1 | OPRK1 | ENSPTRP00000000764 | ENSPTRP00000062600 | Opioid receptor delta 1; Belongs to the G-protein coupled receptor 1 family. | Opioid receptor kappa 1; Belongs to the G-protein coupled receptor 1 family. | 0.944 |
| OPRD1 | OPRL1 | ENSPTRP00000000764 | ENSPTRP00000078089 | Opioid receptor delta 1; Belongs to the G-protein coupled receptor 1 family. | OPRL1 isoform 1; Belongs to the G-protein coupled receptor 1 family. | 0.937 |
| OPRD1 | OPRM1 | ENSPTRP00000000764 | ENSPTRP00000043686 | Opioid receptor delta 1; Belongs to the G-protein coupled receptor 1 family. | Mu-type opioid receptor; Receptor for endogenous opioids such as beta-endorphin and endomorphin. Receptor for natural and synthetic opioids including morphine, heroin, DAMGO, fentanyl, etorphine, buprenorphin and methadone. Agonist binding to the receptor induces coupling to an inactive GDP-bound heterotrimeric G-protein complex and subsequent exchange of GDP for GTP in the G-protein alpha subunit leading to dissociation of the G-protein complex with the free GTP-bound G-protein alpha and the G-protein beta-gamma dimer activating downstream cellular effectors. The agonist- and cell typ [...] | 0.982 |
| OPRD1 | PDYN | ENSPTRP00000000764 | ENSPTRP00000022551 | Opioid receptor delta 1; Belongs to the G-protein coupled receptor 1 family. | PDYN isoform 1. | 0.987 |
| OPRD1 | PENK | ENSPTRP00000000764 | ENSPTRP00000034706 | Opioid receptor delta 1; Belongs to the G-protein coupled receptor 1 family. | PENK isoform 3. | 0.994 |
| OPRD1 | PNOC | ENSPTRP00000000764 | ENSPTRP00000034436 | Opioid receptor delta 1; Belongs to the G-protein coupled receptor 1 family. | Prepronociceptin. | 0.988 |
| OPRD1 | POMC | ENSPTRP00000000764 | ENSPTRP00000052139 | Opioid receptor delta 1; Belongs to the G-protein coupled receptor 1 family. | Proopiomelanocortin. | 0.993 |
| OPRK1 | OPRD1 | ENSPTRP00000062600 | ENSPTRP00000000764 | Opioid receptor kappa 1; Belongs to the G-protein coupled receptor 1 family. | Opioid receptor delta 1; Belongs to the G-protein coupled receptor 1 family. | 0.944 |
| OPRK1 | OPRL1 | ENSPTRP00000062600 | ENSPTRP00000078089 | Opioid receptor kappa 1; Belongs to the G-protein coupled receptor 1 family. | OPRL1 isoform 1; Belongs to the G-protein coupled receptor 1 family. | 0.939 |
