| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CTBP1 | HDAC1 | ENSPTRP00000077481 | ENSPTRP00000075891 | C-terminal binding protein 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. | 0.980 |
| CTBP1 | HDAC2 | ENSPTRP00000077481 | ENSPTRP00000049696 | C-terminal binding protein 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. | 0.991 |
| CTBP1 | KDM1A | ENSPTRP00000077481 | ENSPTRP00000062143 | C-terminal binding protein 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. | 0.948 |
| CTBP1 | RCOR1 | ENSPTRP00000077481 | ENSPTRP00000052457 | C-terminal binding protein 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | REST corepressor 1. | 0.954 |
| CTBP1 | RCOR3 | ENSPTRP00000077481 | ENSPTRP00000003285 | C-terminal binding protein 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | REST corepressor 3. | 0.417 |
| CTBP1 | ZNF217 | ENSPTRP00000077481 | ENSPTRP00000023462 | C-terminal binding protein 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | Zinc finger protein 217. | 0.949 |
| HDAC1 | CTBP1 | ENSPTRP00000075891 | ENSPTRP00000077481 | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. | C-terminal binding protein 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | 0.980 |
| HDAC1 | HDAC2 | ENSPTRP00000075891 | ENSPTRP00000049696 | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. | Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. | 0.999 |
| HDAC1 | HMG20A | ENSPTRP00000075891 | ENSPTRP00000012525 | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. | High mobility group 20A. | 0.863 |
| HDAC1 | HMG20B | ENSPTRP00000075891 | ENSPTRP00000049115 | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. | High mobility group 20B. | 0.891 |
| HDAC1 | KDM1A | ENSPTRP00000075891 | ENSPTRP00000062143 | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. | Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. | 0.943 |
| HDAC1 | PHF21A | ENSPTRP00000075891 | ENSPTRP00000069483 | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. | PHD finger protein 21A. | 0.900 |
| HDAC1 | RCOR1 | ENSPTRP00000075891 | ENSPTRP00000052457 | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. | REST corepressor 1. | 0.986 |
| HDAC1 | RCOR3 | ENSPTRP00000075891 | ENSPTRP00000003285 | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. | REST corepressor 3. | 0.843 |
| HDAC1 | REST | ENSPTRP00000075891 | ENSPTRP00000039730 | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. | RE1 silencing transcription factor. | 0.966 |
| HDAC1 | ZNF217 | ENSPTRP00000075891 | ENSPTRP00000023462 | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. | Zinc finger protein 217. | 0.749 |
| HDAC2 | CTBP1 | ENSPTRP00000049696 | ENSPTRP00000077481 | Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. | C-terminal binding protein 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | 0.991 |
| HDAC2 | HDAC1 | ENSPTRP00000049696 | ENSPTRP00000075891 | Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. | 0.999 |
| HDAC2 | HMG20A | ENSPTRP00000049696 | ENSPTRP00000012525 | Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. | High mobility group 20A. | 0.934 |
| HDAC2 | HMG20B | ENSPTRP00000049696 | ENSPTRP00000049115 | Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. | High mobility group 20B. | 0.951 |
