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The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
BIVMBIVM-ERCC5 isoform 1. (1640 aa)    
Predicted Functional Partners:
ERCC6
ERCC6 isoform 1.
   
 0.989
ERCC2
ERCC excision repair 2, TFIIH core complex helicase subunit.
   
 0.974
WRN
WRN RecQ like helicase.
  
 0.973
ERCC3
ERCC excision repair 3, TFIIH core complex helicase subunit.
   
 0.968
XPA
Xeroderma pigmentosum, complementation group A.
    
 0.955
GTF2H2C
General transcription factor IIH subunit.
    
 0.936
EP300
E1A binding protein p300.
   
 0.920
GTF2H1
General transcription factor IIH, polypeptide 1, 62kDa.
    
 0.920
CK820_G0005641
GTF2H1 isoform 5.
    
 0.920
MUS81
MUS81 structure-specific endonuclease subunit.
   
 0.913
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.