| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| DAXX | PTEN | ENSPTRP00000030818 | ENSPTRP00000090779 | Death domain associated protein. | Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. | 0.643 |
| DAXX | TP53 | ENSPTRP00000030818 | ENSPTRP00000014836 | Death domain associated protein. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | 0.994 |
| DAXX | UBC | ENSPTRP00000030818 | ENSPTRP00000050925 | Death domain associated protein. | Polyubiquitin-C; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair [...] | 0.453 |
| DAXX | USP7 | ENSPTRP00000030818 | ENSPTRP00000075972 | Death domain associated protein. | Ubiquitin specific peptidase 7; Belongs to the peptidase C19 family. | 0.979 |
| FOXO1 | FOXO3 | ENSPTRP00000009886 | ENSPTRP00000049754 | FOXO1 isoform 1. | FOXO3 isoform 1. | 0.962 |
| FOXO1 | FOXO4 | ENSPTRP00000009886 | ENSPTRP00000059402 | FOXO1 isoform 1. | Forkhead box O4. | 0.664 |
| FOXO1 | PTEN | ENSPTRP00000009886 | ENSPTRP00000090779 | FOXO1 isoform 1. | Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. | 0.706 |
| FOXO1 | TP53 | ENSPTRP00000009886 | ENSPTRP00000014836 | FOXO1 isoform 1. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | 0.795 |
| FOXO1 | USP7 | ENSPTRP00000009886 | ENSPTRP00000075972 | FOXO1 isoform 1. | Ubiquitin specific peptidase 7; Belongs to the peptidase C19 family. | 0.956 |
| FOXO3 | FOXO1 | ENSPTRP00000049754 | ENSPTRP00000009886 | FOXO3 isoform 1. | FOXO1 isoform 1. | 0.962 |
| FOXO3 | FOXO4 | ENSPTRP00000049754 | ENSPTRP00000059402 | FOXO3 isoform 1. | Forkhead box O4. | 0.699 |
| FOXO3 | PTEN | ENSPTRP00000049754 | ENSPTRP00000090779 | FOXO3 isoform 1. | Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. | 0.662 |
| FOXO3 | TP53 | ENSPTRP00000049754 | ENSPTRP00000014836 | FOXO3 isoform 1. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | 0.915 |
| FOXO3 | USP7 | ENSPTRP00000049754 | ENSPTRP00000075972 | FOXO3 isoform 1. | Ubiquitin specific peptidase 7; Belongs to the peptidase C19 family. | 0.969 |
| FOXO4 | FOXO1 | ENSPTRP00000059402 | ENSPTRP00000009886 | Forkhead box O4. | FOXO1 isoform 1. | 0.664 |
| FOXO4 | FOXO3 | ENSPTRP00000059402 | ENSPTRP00000049754 | Forkhead box O4. | FOXO3 isoform 1. | 0.699 |
| FOXO4 | PTEN | ENSPTRP00000059402 | ENSPTRP00000090779 | Forkhead box O4. | Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. | 0.616 |
| FOXO4 | TP53 | ENSPTRP00000059402 | ENSPTRP00000014836 | Forkhead box O4. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | 0.774 |
| FOXO4 | USP7 | ENSPTRP00000059402 | ENSPTRP00000075972 | Forkhead box O4. | Ubiquitin specific peptidase 7; Belongs to the peptidase C19 family. | 0.977 |
| PTEN | DAXX | ENSPTRP00000090779 | ENSPTRP00000030818 | Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. | Death domain associated protein. | 0.643 |
