GATA2 protein (Pan troglodytes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc.

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TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

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structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

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node degree of proteins in your network (given the current score cut-off)

... network coordinates:

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a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EP300	FOXA1	ENSPTRP00000024841	ENSPTRP00000062658	E1A binding protein p300.	FOXA1 isoform 1.	0.862
EP300	GATA2	ENSPTRP00000024841	ENSPTRP00000054198	E1A binding protein p300.	GATA binding protein 2.	0.783
EP300	GATA3	ENSPTRP00000024841	ENSPTRP00000064658	E1A binding protein p300.	GATA binding protein 3.	0.936
EP300	RUNX1	ENSPTRP00000024841	ENSPTRP00000092866	E1A binding protein p300.	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.	0.888
EP300	SPI1	ENSPTRP00000024841	ENSPTRP00000084012	E1A binding protein p300.	Spi-1 proto-oncogene.	0.828
EP300	TAL1	ENSPTRP00000024841	ENSPTRP00000063843	E1A binding protein p300.	TAL bHLH transcription factor 1, erythroid differentiation factor.	0.775
EP300	TCF12	ENSPTRP00000024841	ENSPTRP00000012156	E1A binding protein p300.	Transcription factor 12.	0.782
EP300	ZFPM1	ENSPTRP00000024841	ENSPTRP00000014414	E1A binding protein p300.	ZFPM1 isoform 1.	0.464
FOXA1	EP300	ENSPTRP00000062658	ENSPTRP00000024841	FOXA1 isoform 1.	E1A binding protein p300.	0.862
FOXA1	GATA2	ENSPTRP00000062658	ENSPTRP00000054198	FOXA1 isoform 1.	GATA binding protein 2.	0.797
FOXA1	GATA3	ENSPTRP00000062658	ENSPTRP00000064658	FOXA1 isoform 1.	GATA binding protein 3.	0.984
GATA2	EP300	ENSPTRP00000054198	ENSPTRP00000024841	GATA binding protein 2.	E1A binding protein p300.	0.783
GATA2	FOXA1	ENSPTRP00000054198	ENSPTRP00000062658	GATA binding protein 2.	FOXA1 isoform 1.	0.797
GATA2	GATA3	ENSPTRP00000054198	ENSPTRP00000064658	GATA binding protein 2.	GATA binding protein 3.	0.844
GATA2	LDB1	ENSPTRP00000054198	ENSPTRP00000040252	GATA binding protein 2.	LIM domain binding 1.	0.863
GATA2	LMO2	ENSPTRP00000054198	ENSPTRP00000071226	GATA binding protein 2.	LIM domain only 2.	0.860
GATA2	RUNX1	ENSPTRP00000054198	ENSPTRP00000092866	GATA binding protein 2.	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.	0.853
GATA2	SPI1	ENSPTRP00000054198	ENSPTRP00000084012	GATA binding protein 2.	Spi-1 proto-oncogene.	0.945
GATA2	TAL1	ENSPTRP00000054198	ENSPTRP00000063843	GATA binding protein 2.	TAL bHLH transcription factor 1, erythroid differentiation factor.	0.964
GATA2	TCF12	ENSPTRP00000054198	ENSPTRP00000012156	GATA binding protein 2.	Transcription factor 12.	0.823