STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
HRH2Histamine H2 receptor; The H2 subclass of histamine receptors mediates gastric acid secretion. Also appears to regulate gastrointestinal motility and intestinal secretion. Possible role in regulating cell growth and differentiation. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and, through a separate G protein-dependent mechanism, the phosphoinositide/protein kinase (PKC) signaling pathway (By similarity); Belongs to the G-protein coupled receptor 1 family. (482 aa)    
Predicted Functional Partners:
GNAS
GNAS isoform 19.
    
 0.964
LOC104003639
Guanine nucleotide-binding protein G(s) subunit alpha.
    
  0.917
CK820_G0055106
IGHV3-66 isoform 1.
    
   0.905
GNAL
G protein subunit alpha L.
    
 0.838
IGHV3OR16-13
IGHV3-74 isoform 1.
    
   0.810
IGKV1D-43
IGKV1-39 isoform 1.
    
  0.806
HDC
Histidine decarboxylase.
      
 0.696
ATP12A
Sodium/potassium-transporting ATPase subunit alpha.
      
 0.674
ATP4A
Sodium/potassium-transporting ATPase subunit alpha.
      
 0.674
GAST
GAST isoform 1.
   
 0.639
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.