KIR3DX1-2 protein (Pan troglodytes) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

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co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

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Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
GNL1	KIR3DX1-2	ENSPTRP00000070705	ENSPTRP00000054284	Guanine nucleotide-binding protein-like 1; Possible regulatory or functional link with the histocompatibility cluster.	KIR3DX1 isoform 7.	0.433
GNL1	PPP1R11	ENSPTRP00000070705	ENSPTRP00000084274	Guanine nucleotide-binding protein-like 1; Possible regulatory or functional link with the histocompatibility cluster.	E3 ubiquitin-protein ligase PPP1R11; Atypical E3 ubiquitin-protein ligase which ubiquitinates TLR2 at 'Lys-754' leading to its degradation by the proteasome. Plays a role in regulating inflammatory cytokine release and gram-positive bacterial clearance by functioning, in part, through the ubiquitination and degradation of TLR2. Inhibitor of protein phosphatase 1.	0.631
GNL1	PRR3	ENSPTRP00000070705	ENSPTRP00000063386	Guanine nucleotide-binding protein-like 1; Possible regulatory or functional link with the histocompatibility cluster.	Proline-rich protein 3.	0.672
GNL1	RPP21	ENSPTRP00000070705	ENSPTRP00000050429	Guanine nucleotide-binding protein-like 1; Possible regulatory or functional link with the histocompatibility cluster.	E3 ubiquitin-protein ligase TRIM39; E3 ubiquitin-protein ligase (By similarity). May facilitate apoptosis by inhibiting APC/C-Cdh1-mediated poly-ubiquitination and subsequent proteasome-mediated degradation of the pro-apoptotic protein MOAP1 (By similarity). Regulates the G1/S transition of the cell cycle and DNA damage-induced G2 arrest by stabilizing CDKN1A/p21 (By similarity). Positively regulates CDKN1A/p21 stability by competing with DTL for CDKN1A/p21 binding, therefore disrupting DCX(DTL) E3 ubiquitin ligase complex-mediated CDKN1A/p21 ubiquitination and degradation (By similari [...]	0.510
KIR3DX1-2	GNL1	ENSPTRP00000054284	ENSPTRP00000070705	KIR3DX1 isoform 7.	Guanine nucleotide-binding protein-like 1; Possible regulatory or functional link with the histocompatibility cluster.	0.433
KIR3DX1-2	LAIR2-2	ENSPTRP00000054284	ENSPTRP00000073662	KIR3DX1 isoform 7.	Leukocyte associated immunoglobulin like receptor 2.	0.516
KIR3DX1-2	PATR-AL	ENSPTRP00000054284	ENSPTRP00000068372	KIR3DX1 isoform 7.	Major histocompatibility complex, class I, AL precursor.	0.402
KIR3DX1-2	PATR-F	ENSPTRP00000054284	ENSPTRP00000054635	KIR3DX1 isoform 7.	Patr class I histocompatibility antigen, CH28 alpha chain; Involved in the presentation of foreign antigens to the immune system.	0.568
KIR3DX1-2	PPP1R11	ENSPTRP00000054284	ENSPTRP00000084274	KIR3DX1 isoform 7.	E3 ubiquitin-protein ligase PPP1R11; Atypical E3 ubiquitin-protein ligase which ubiquitinates TLR2 at 'Lys-754' leading to its degradation by the proteasome. Plays a role in regulating inflammatory cytokine release and gram-positive bacterial clearance by functioning, in part, through the ubiquitination and degradation of TLR2. Inhibitor of protein phosphatase 1.	0.473
KIR3DX1-2	PRR3	ENSPTRP00000054284	ENSPTRP00000063386	KIR3DX1 isoform 7.	Proline-rich protein 3.	0.619
KIR3DX1-2	RPP21	ENSPTRP00000054284	ENSPTRP00000050429	KIR3DX1 isoform 7.	E3 ubiquitin-protein ligase TRIM39; E3 ubiquitin-protein ligase (By similarity). May facilitate apoptosis by inhibiting APC/C-Cdh1-mediated poly-ubiquitination and subsequent proteasome-mediated degradation of the pro-apoptotic protein MOAP1 (By similarity). Regulates the G1/S transition of the cell cycle and DNA damage-induced G2 arrest by stabilizing CDKN1A/p21 (By similarity). Positively regulates CDKN1A/p21 stability by competing with DTL for CDKN1A/p21 binding, therefore disrupting DCX(DTL) E3 ubiquitin ligase complex-mediated CDKN1A/p21 ubiquitination and degradation (By similari [...]	0.409
KIR3DX1-2	TRIM10	ENSPTRP00000054284	ENSPTRP00000030567	KIR3DX1 isoform 7.	Tripartite motif-containing protein 10; Seems to play an important role in erythropoiesis.	0.473
LAIR2-2	KIR3DX1-2	ENSPTRP00000073662	ENSPTRP00000054284	Leukocyte associated immunoglobulin like receptor 2.	KIR3DX1 isoform 7.	0.516
PATR-AL	KIR3DX1-2	ENSPTRP00000068372	ENSPTRP00000054284	Major histocompatibility complex, class I, AL precursor.	KIR3DX1 isoform 7.	0.402
PATR-AL	PPP1R11	ENSPTRP00000068372	ENSPTRP00000084274	Major histocompatibility complex, class I, AL precursor.	E3 ubiquitin-protein ligase PPP1R11; Atypical E3 ubiquitin-protein ligase which ubiquitinates TLR2 at 'Lys-754' leading to its degradation by the proteasome. Plays a role in regulating inflammatory cytokine release and gram-positive bacterial clearance by functioning, in part, through the ubiquitination and degradation of TLR2. Inhibitor of protein phosphatase 1.	0.474
PATR-F	KIR3DX1-2	ENSPTRP00000054635	ENSPTRP00000054284	Patr class I histocompatibility antigen, CH28 alpha chain; Involved in the presentation of foreign antigens to the immune system.	KIR3DX1 isoform 7.	0.568
PPP1R11	GNL1	ENSPTRP00000084274	ENSPTRP00000070705	E3 ubiquitin-protein ligase PPP1R11; Atypical E3 ubiquitin-protein ligase which ubiquitinates TLR2 at 'Lys-754' leading to its degradation by the proteasome. Plays a role in regulating inflammatory cytokine release and gram-positive bacterial clearance by functioning, in part, through the ubiquitination and degradation of TLR2. Inhibitor of protein phosphatase 1.	Guanine nucleotide-binding protein-like 1; Possible regulatory or functional link with the histocompatibility cluster.	0.631
PPP1R11	KIR3DX1-2	ENSPTRP00000084274	ENSPTRP00000054284	E3 ubiquitin-protein ligase PPP1R11; Atypical E3 ubiquitin-protein ligase which ubiquitinates TLR2 at 'Lys-754' leading to its degradation by the proteasome. Plays a role in regulating inflammatory cytokine release and gram-positive bacterial clearance by functioning, in part, through the ubiquitination and degradation of TLR2. Inhibitor of protein phosphatase 1.	KIR3DX1 isoform 7.	0.473
PPP1R11	PATR-AL	ENSPTRP00000084274	ENSPTRP00000068372	E3 ubiquitin-protein ligase PPP1R11; Atypical E3 ubiquitin-protein ligase which ubiquitinates TLR2 at 'Lys-754' leading to its degradation by the proteasome. Plays a role in regulating inflammatory cytokine release and gram-positive bacterial clearance by functioning, in part, through the ubiquitination and degradation of TLR2. Inhibitor of protein phosphatase 1.	Major histocompatibility complex, class I, AL precursor.	0.474
PPP1R11	PRR3	ENSPTRP00000084274	ENSPTRP00000063386	E3 ubiquitin-protein ligase PPP1R11; Atypical E3 ubiquitin-protein ligase which ubiquitinates TLR2 at 'Lys-754' leading to its degradation by the proteasome. Plays a role in regulating inflammatory cytokine release and gram-positive bacterial clearance by functioning, in part, through the ubiquitination and degradation of TLR2. Inhibitor of protein phosphatase 1.	Proline-rich protein 3.	0.681