STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
C5AR1C5a anaphylatoxin chemotactic receptor 1; Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a. The ligand interacts with at least two sites on the receptor: a high-affinity site on the extracellular N-terminus, and a second site in the transmembrane region which activates downstream signaling events. Receptor activation stimulates chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production. (351 aa)    
Predicted Functional Partners:
C5
Complement C5.
    
 0.968
C1QC
Complement C1q C chain.
   
  
 0.588
TNFSF13B
Tumor necrosis factor ligand 7A; Belongs to the tumor necrosis factor family.
   
 
 0.564
ITGAL
ITGAL isoform 4.
   
  
 0.492
DOCK2
Dedicator of cytokinesis 2; Belongs to the DOCK family.
   
  
 0.483
C8A
C8A isoform 1.
     
 0.477
ITGB2
Integrin beta.
   
  
 0.474
CCL26
C-C motif chemokine.
      
 0.469
CFP
Complement factor properdin.
   
 
 0.468
C3AR1
Complement C3a receptor 1; Belongs to the G-protein coupled receptor 1 family.
   
 
0.463
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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