TNF protein (Pan troglodytes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADAM17	TNF	ENSPTRP00000052198	ENSPTRP00000069905	ADAM17 isoform 3.	Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...]	0.995
ADAM17	TNFRSF1A	ENSPTRP00000052198	ENSPTRP00000066030	ADAM17 isoform 3.	Tumor necrosis factor receptor superfamily, member 1A.	0.503
ADAM17	TNFRSF1B	ENSPTRP00000052198	ENSPTRP00000000311	ADAM17 isoform 3.	Tumor necrosis factor receptor superfamily, member 1B.	0.726
IFNG	NFKB1	ENSPTRP00000008822	ENSPTRP00000028033	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity).	Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1.	0.704
IFNG	RELA	ENSPTRP00000008822	ENSPTRP00000054405	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity).	V-rel reticuloendotheliosis viral oncogene homolog A (Avian).	0.439
IFNG	TNF	ENSPTRP00000008822	ENSPTRP00000069905	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity).	Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...]	0.988
IFNG	TNFRSF1A	ENSPTRP00000008822	ENSPTRP00000066030	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity).	Tumor necrosis factor receptor superfamily, member 1A.	0.594
IFNG	TRAF6	ENSPTRP00000008822	ENSPTRP00000006096	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity).	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.558
NFKB1	IFNG	ENSPTRP00000028033	ENSPTRP00000008822	Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity).	0.704
NFKB1	RELA	ENSPTRP00000028033	ENSPTRP00000054405	Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1.	V-rel reticuloendotheliosis viral oncogene homolog A (Avian).	0.999
NFKB1	RIPK1	ENSPTRP00000028033	ENSPTRP00000030180	Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1.	Receptor (TNFRSF)-interacting serine-threonine kinase 1.	0.626
NFKB1	TNF	ENSPTRP00000028033	ENSPTRP00000069905	Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1.	Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...]	0.990
NFKB1	TNFAIP3	ENSPTRP00000028033	ENSPTRP00000031827	Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1.	Tumor necrosis factor, alpha-induced protein 3.	0.679
NFKB1	TNFRSF1A	ENSPTRP00000028033	ENSPTRP00000066030	Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1.	Tumor necrosis factor receptor superfamily, member 1A.	0.621
NFKB1	TNFRSF1B	ENSPTRP00000028033	ENSPTRP00000000311	Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1.	Tumor necrosis factor receptor superfamily, member 1B.	0.525
NFKB1	TRADD	ENSPTRP00000028033	ENSPTRP00000046129	Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1.	TNFRSF1A-associated via death domain.	0.553
NFKB1	TRAF6	ENSPTRP00000028033	ENSPTRP00000006096	Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.800
RELA	IFNG	ENSPTRP00000054405	ENSPTRP00000008822	V-rel reticuloendotheliosis viral oncogene homolog A (Avian).	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity).	0.439
RELA	NFKB1	ENSPTRP00000054405	ENSPTRP00000028033	V-rel reticuloendotheliosis viral oncogene homolog A (Avian).	Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1.	0.999
RELA	RIPK1	ENSPTRP00000054405	ENSPTRP00000030180	V-rel reticuloendotheliosis viral oncogene homolog A (Avian).	Receptor (TNFRSF)-interacting serine-threonine kinase 1.	0.434