STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (234 aa)    
Predicted Functional Partners:
TNFRSF1B
Tumor necrosis factor receptor superfamily, member 1B.
   
 0.999
TNFRSF1A
Tumor necrosis factor receptor superfamily, member 1A.
    
 0.999
TRADD
TNFRSF1A-associated via death domain.
    
 0.998
RIPK1
Receptor (TNFRSF)-interacting serine-threonine kinase 1.
   
 0.997
TRAF2
TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.
   
 0.997
CASP8
Caspase 8, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family.
   
 
 0.996
TNFAIP3
Tumor necrosis factor, alpha-induced protein 3.
   
 0.996
IKBKB
Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta.
   
 0.996
IKBKG
Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma.
    
 0.996
CHUK
Component of inhibitor of nuclear factor kappa B kinase complex.
   
 0.996
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.